Lee Barrett

TL;DR: Axon regeneration is arrested in the injured central nervous system (CNS) by axon growth-inhibitory ligands expressed in oligodendrocytes/myelin, NG2-glia, and reactive astrocyte in the lesion and degenerating tracts, and by fibroblasts in scar tissue.

TL;DR: It is proposed that rapid plasma elimination of polycation/DNA complexes results from their binding serum albumin and other proteins, perhaps due to aggregation and phagocytic capture or accumulation of the ternary complexes in fine capillary beds.

TL;DR: Data reveal that T-cell infiltration and activation in the dorsal horn of the spinal cord following peripheral nerve injury contribute to the evolution of neuropathic pain-like hypersensitivity, and shows that IFNγ signaling is required for full expression of adult neuropathic hypersensitivity.

TL;DR: Results demonstrate that HIS RPCs represent a novel and versatile type of vector that can be used for efficient cytoplasmic delivery of a broad range of nucleic acids.

TL;DR: This work used a comprehensive systems biology approach, starting with gene expression profiling of dorsal root ganglia (DRGs) combined with multi-level bioinformatic analyses and experimental validation of network predictions, to identify a drug that accelerates DRG neurite out growth in vitro and optic nerve outgrowth in vivo by inducing elements of the identified network.