Vijayendran Chandran

TL;DR: It is shown that the patterns of ASD and ID risk genes are distinct, providing a biological framework for further investigating the pathophysiology of ASD.

TL;DR: This work used a comprehensive systems biology approach, starting with gene expression profiling of dorsal root ganglia (DRGs) combined with multi-level bioinformatic analyses and experimental validation of network predictions, to identify a drug that accelerates DRG neurite out growth in vitro and optic nerve outgrowth in vivo by inducing elements of the identified network.

TL;DR: A systematic map of SCD effects on gene function by analyzing genome-wide expression data in humans with diverse sex-chromosome aneuploidies and demonstrating a pattern of obligate dosage sensitivity among evolutionarily preserved X-Y homologs is developed.

TL;DR: It is demonstrated that the onset of cold hypersensitivity precedes tactile allodynia in a model of partial nerve injury, and this temporal divergence was associated with major differences in global gene expression in innervating dorsal root ganglia.

TL;DR: Analysis of co-expression networks in Timothy syndrome shows how a systems biology approach based on gene networks can yield insights into the molecular mechanisms of neural development and function, and provide clues as to the functional impact of the downstream effects of Ca2+ signaling dysregulation on transcription.