L
Lei Guo
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 15
Citations - 556
Lei Guo is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Biology & Disease. The author has an hindex of 6, co-authored 11 publications receiving 189 citations. Previous affiliations of Lei Guo include University of North Dakota.
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Journal ArticleDOI
The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer’s disease
Ji-Yeun Hur,Georgia R. Frost,Georgia R. Frost,Xianzhong Wu,Christina J. Crump,Christina J. Crump,Si Jia Pan,Eitan Wong,Marília A. S. Barros,Thomas Li,Thomas Li,Pengju Nie,Pengju Nie,Yujia Zhai,Jen Chyong Wang,Julia Tcw,Lei Guo,Andrew M. McKenzie,Chen Ming,Xianxiao Zhou,Minghui Wang,Yotam Sagi,Alan E. Renton,Bianca T. Esposito,Yong Kim,Katherine R. Sadleir,Ivy Trinh,Robert A. Rissman,Robert Vassar,Bin Zhang,Douglas S. Johnson,Eliezer Masliah,Paul Greengard,Alison Goate,Yue-Ming Li,Yue-Ming Li +35 more
TL;DR: A mechanism in which γ-secretase is modulated by neuroinflammation via IFITM3 and the risk of Alzheimer’s disease is thereby increased is revealed.
Journal ArticleDOI
Microglia and macrophages promote corralling, wound compaction and recovery after spinal cord injury via Plexin-B2.
Xiang Zhou,Xiang Zhou,Shalaka Wahane,Marie-Sophie Friedl,Michael Kluge,Caroline C. Friedel,Kleopatra Avrampou,Venetia Zachariou,Lei Guo,Bin Zhang,Xijing He,Roland H. Friedel,Hongyan Zou +12 more
TL;DR: Examining a temporally distinct gene signature in injury-activated microglia and macrophages that engages axon guidance pathways establishes Plexin-B2 as an important link that integrates biochemical cues and physical interactions of IAMs with the injury microenvironment during wound healing.
Journal ArticleDOI
Molecular subtyping of Alzheimer’s disease using RNA sequencing data reveals novel mechanisms and targets
Ryan Neff,Minghui Wang,Sezen Vatansever,Lei Guo,Chen Ming,Qian Wang,Erming Wang,Emrin Horgusluoglu-Moloch,Won-Min Song,Aiqun Li,Emilie L. Castranio,Julia Tcw,Lap Ho,Alison Goate,Valentina Fossati,Scott Noggle,Sam Gandy,Michelle E. Ehrlich,Pavel Katsel,Pavel Katsel,Eric E. Schadt,Dongming Cai,Dongming Cai,Kristen J. Brennand,Vahram Haroutunian,Bin Zhang +25 more
TL;DR: In this article, the authors identify three major molecular subtypes of Alzheimer's disease corresponding to different combinations of multiple dysregulated pathways, such as susceptibility to tau-mediated neurodegeneration, amyloid-β neuroinflammation, synaptic signaling, immune activity, mitochondria organization, and myelination.
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Transformative Network Modeling of Multi-omics Data Reveals Detailed Circuits, Key Regulators, and Potential Therapeutics for Alzheimer’s Disease
Minghui Wang,Aiqun Li,Michiko Sekiya,Noam D. Beckmann,Xiuming Quan,Nadine Schrode,Michael B. Fernando,Alex J. Yu,Li Zhu,Li Zhu,Jiqing Cao,Jiqing Cao,Liwei Lyu,Emrin Horgusluoglu,Qian Wang,Lei Guo,Yuan-shuo Wang,Ryan Neff,Won-Min Song,Erming Wang,Qi Shen,Xianxiao Zhou,Chen Ming,Seok-Man Ho,Sezen Vatansever,H. Ümit Kaniskan,Jian Jin,Ming-Ming Zhou,Kanae Ando,Lap Ho,Paul A. Slesinger,Zhenyu Yue,Jun Zhu,Pavel Katsel,Pavel Katsel,Sam Gandy,Michelle E. Ehrlich,Valentina Fossati,Scott Noggle,Dongming Cai,Dongming Cai,Vahram Haroutunian,Koichi M. Iijima,Eric E. Schadt,Kristen J. Brennand,Bin Zhang +45 more
TL;DR: This study provides not only a global landscape but also detailed signaling circuits of complex molecular interactions in key brain regions affected by LOAD, and the resulting network models will serve as a blueprint for developing next-generation therapeutic agents against LOAD.
Journal ArticleDOI
Sex Differences in Alzheimer's Disease: Insights From the Multiomics Landscape.
TL;DR: In this paper, the impact of sex chromosomes and sex hormones on Alzheimer's disease (AD) and the interplay between sex and a major AD genetic risk factor, the APOE e4 genotype, through the multiomics landscape.