L
Leif Bertilsson
Researcher at Karolinska University Hospital
Publications - 321
Citations - 24620
Leif Bertilsson is an academic researcher from Karolinska University Hospital. The author has contributed to research in topics: Debrisoquine & Debrisoquin. The author has an hindex of 87, co-authored 321 publications receiving 23933 citations. Previous affiliations of Leif Bertilsson include Astra & University of Oulu.
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Journal ArticleDOI
Pharmacokinetics of nortriptyline and its 10-hydroxy metabolite in Chinese subjects of different CYP2D6 genotypes.
Q. Y. Yue,Zhi‐Hui Zhong,Gunnel Tybring,Per Dalén,Marja-Liisa Dahl,Leif Bertilsson,Folke Sjöqvist +6 more
TL;DR: To study the impact of the CYP2D6*10 allele on the disposition of nortriptyline in Chinese subjects, a large number of subjects were randomly assigned to either the H1N1 or H2N2 allele.
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Mass fragmentographic quantitation of glutamic acid and γ-aminobutyric acid in cerebellar nuclei and sympathetic ganglia of rats
Leif Bertilsson,Erminio Costa +1 more
TL;DR: A method for the simultaneous quantitation of glutamic acid and gamma-aminobutyric acid (GABA) in tissue by mass fragmentography has been developed and has been demonstrated by measurements in parts of rat cerebellum and in the superior cervical ganglion.
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Amitriptyline metabolism: association with debrisoquin hydroxylation in nonsmokers.
TL;DR: The data suggest that there may be a common regulation of the hydroxylation of D and the oxidative metabolism of amitriptyline in nonsmokers, and it is hypothesized that an additional demethylase/hydroxylase is induced in smokers that is not involved in D hydroxyation.
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Low daily 10-mg and 20-mg doses of fluvoxamine inhibit the metabolism of both caffeine (cytochrome P4501A2) and omeprazole (cytochrome P4502C19).
Magnus Christensen,Magnus Christensen,Gunnel Tybring,Gunnel Tybring,Kazuo Mihara,Kazuo Mihara,Norio Yasui‐Furokori,Norio Yasui‐Furokori,Juan Antonio Carrillo,Juan Antonio Carrillo,Sara I. Ramos,Sara I. Ramos,Katarina Andersson,Katarina Andersson,Marja-Liisa Dahl,Marja-Liisa Dahl,Leif Bertilsson,Leif Bertilsson +17 more
TL;DR: Whether nontherapeutic doses of fluvoxamine inhibit CYP1A2 but possibly not CYP2C19 is investigated.
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Inhibition of the sulfoxidation of omeprazole by ketoconazole in poor and extensive metabolizers of S‐mephenytoin
TL;DR: Ketoconazole was used as a probe to investigate the extent to which CYP3A4 is involved in omeprazole metabolism in vivo and to speculate on the predominant pathway in individuals devoid of the genetically determined CYP2C19 activity.