L
Leif Bertilsson
Researcher at Karolinska University Hospital
Publications - 321
Citations - 24620
Leif Bertilsson is an academic researcher from Karolinska University Hospital. The author has contributed to research in topics: Debrisoquine & Debrisoquin. The author has an hindex of 87, co-authored 321 publications receiving 23933 citations. Previous affiliations of Leif Bertilsson include Astra & University of Oulu.
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Book ChapterDOI
Disposition of the Neuroleptics Perphenazine, Zuclopenthixol, and Haloperidol Cosegregates with Polymorphic Debrisoquine Hydroxylation
TL;DR: One of the major aims in optimizing neuroleptic treatment has been to search for concentration-effect rather than dose-effect relationships as discussed by Baldessarini et al. (1988).
Journal ArticleDOI
d-Propoxyphene is a potent inhibitor of debrisoquine, but not S-mephenytoin 4-hydroxylation in vivo.
Emilio J. Sanz,Leif Bertilsson +1 more
TL;DR: It is shown that d-propoxyphene is a potent inhibitor of debrisoquine, but not of S-mephenytoin 4-hydroxylase in vivo.
Journal ArticleDOI
Clinically significant CYP2C inhibition by noscapine but not by glucosamine.
Staffan Rosenborg,Stenberg M,Otto S,Ostervall J,Michèle Masquelier,Qun-Ying Yue,Leif Bertilsson,Erik Eliasson +7 more
TL;DR: Noscapine‐dependent inhibition of CYP2C9 may explain the interaction with warfarin and the effects of these drugs on various cytochrome P450 activity markers.
Journal ArticleDOI
Comparison of N-Acetyltransferase-2 Enzyme Genotype-Phenotype and Xanthine Oxidase Enzyme Activity Between Swedes and Koreans
Natasa Djordjevic,Natasa Djordjevic,Juan Antonio Carrillo,Hyung-Keun Roh,Sara Karlsson,N. Ueda,Leif Bertilsson,Eleni Aklillu +7 more
TL;DR: It is concluded that Koreans display higher NAT2 activity than Swedes regardless of NAT2 genotype, whereas sex is the only determinant of XO activity.
Journal ArticleDOI
Stereoselective efflux of (E)-10-hydroxynortriptyline enantiomers from the cerebrospinal fluid of depressed patients.
TL;DR: There was a correlation between the concentration of 10-OH-NT (sum of enantiomers) in CSF and plasma ultrafiltrate and this seems to be due to a stereoselective transport of (E)-10- OH-NT out from the CSF.