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Leif Bertilsson

Researcher at Karolinska University Hospital

Publications -  321
Citations -  24620

Leif Bertilsson is an academic researcher from Karolinska University Hospital. The author has contributed to research in topics: Debrisoquine & Debrisoquin. The author has an hindex of 87, co-authored 321 publications receiving 23933 citations. Previous affiliations of Leif Bertilsson include Astra & University of Oulu.

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Journal ArticleDOI

Gradients of monoamine metabolites and cortisol in cerebrospinal fluid of psychiatric patients and healthy controls.

Leif Bertilsson, +5 more
- 01 Feb 1982 - 
TL;DR: There were pronounced concentration gradients for both 5-hydroxyindoleacetic acid and homovanillic acid, and in psychiatric patients there was a slight, but statistically significant concentration gradient for 3-methoxy-4-hydroxyphenylglycol (unconjugated as well as conjugated).
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CYP3A induction and inhibition by different antiretroviral regimens reflected by changes in plasma 4β-hydroxycholesterol levels

Filip Josephson, +7 more
- 06 May 2008 - 
TL;DR: Changes in plasma 4β-hydroxycholesterol following the initiation of efavirenz- or atazanavir/ritonavir-based antiretroviral therapy reflected the respective net increase and decrease of CYP3A activity of these regimens.
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Active hydroxymetabolites of antidepressants. Emphasis on E-10-hydroxy-nortriptyline

Conny Nordin, +1 more
- 01 Jan 1995 - 
TL;DR: During treatment with nortriptyline, hydroxymetabolites exert, at least in some patients, major effects on brain noradrenaline neurons, which might contribute to biochemical and clinical effects during treatment with antidepressants.
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Individualized medicine - implementation of pharmacogenetic diagnostics in antidepressant drug treatment of major depressive disorders.

Julia Kirchheiner, +5 more
- 01 Nov 2003 - 
TL;DR: A pharmacogenomic approach to individualize antidepressant drug treatment is recommended to be based on several levels: identifying and validating the candidate genes involved in drug-response; providing therapeutic guidelines; and developing a pharmacogenetic test-system for bedside-genotyping.
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Disassociation between debrisoquine hydroxylation phenotype and genotype among chinese

Q. Y. Yue, +6 more
- 07 Oct 1989 - 
TL;DR: 1. Trophoblast cells in maternal blood from pregnant women and the detection and isolation using the fluorescence-activated cell sorter (FACS).