L
Leif Bertilsson
Researcher at Karolinska University Hospital
Publications - 321
Citations - 24620
Leif Bertilsson is an academic researcher from Karolinska University Hospital. The author has contributed to research in topics: Debrisoquine & Debrisoquin. The author has an hindex of 87, co-authored 321 publications receiving 23933 citations. Previous affiliations of Leif Bertilsson include Astra & University of Oulu.
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Journal ArticleDOI
Molecular basis for rational megaprescribing in ultrarapid hydroxylators of debrisoquine.
Leif Bertilsson,M-L Dahl,Folke Sjöqvist,Anna Åberg-Wistedt,Mats B. Humble,Inger Johansson,Eva Lundqvist,Magnus Ingelman-Sundberg +7 more
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Use of omeprazole as a probe drug for CYP2C19 phenotype in Swedish Caucasians: comparison with S-mephenytoin hydroxylation phenotype and CYP2C19 genotype
TL;DR: The phenotype determined by omeprazole correlated with that of mephenytoin, and was in good agreement with the genotype.
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The involvement of CYP1A2 and CYP3A4 in the metabolism of clozapine
TL;DR: It is concluded that CYP1A2 and CYP3A4 are involved in the demethylation of CLZ and CyP3a4 in the N-oxidation ofCLZ.
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Interphenotype differences in disposition and effect on gastrin levels of omeprazole—suitability of omeprazole as a probe for CYP2C19.
Ming Chang,Gunnel Tybring,Marja-Liisa Dahl,Eva Gotharson,M Sagar,R. Seensalu,Leif Bertilsson +6 more
TL;DR: Concentrations of hydroxyomeprazole were higher in EM than in PM confirming that the hydroxy, but not the sulphone metabolite, is formed by the S-mephenytoin hydroxylase (CYP2C19).
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A novel mutant variant of the CYP2D6 gene (CYP2D617) common in a black African population: association with diminished debrisoquine hydroxylase activity
TL;DR: It is postulated that the CYP2D6*17 allele might contribute to the molecular basis of the previously established diminished debrisoquine hydroxylase activity in African Bantu populations.