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Leif Bertilsson

Researcher at Karolinska University Hospital

Publications -  321
Citations -  24620

Leif Bertilsson is an academic researcher from Karolinska University Hospital. The author has contributed to research in topics: Debrisoquine & Debrisoquin. The author has an hindex of 87, co-authored 321 publications receiving 23933 citations. Previous affiliations of Leif Bertilsson include Astra & University of Oulu.

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Journal ArticleDOI

Genetic polymorphism of CYP1A2 in Ethiopians affecting induction and expression: characterization of novel haplotypes with single-nucleotide polymorphisms in intron 1.

Eleni Aklillu, +6 more
- 01 Sep 2003 - 
TL;DR: A novel polymorphism in intron 1 of importance for Ets-dependent CYP1A2 expression in vivo and inducibility of the enzyme is indicated, which might be of critical importance for determination of interindividual differences in drug metabolism and sensitivity to carcinogens activated by CYP 1A2.
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4β-hydroxycholesterol, an endogenous marker of CYP3A4/5 activity in humans

Ulf Diczfalusy, +3 more
- 01 Feb 2011 - 
TL;DR: The concentration of 4β-OHC was higher in women than in men, confirming previous studies indicating a gender difference in CYP3A4/5-activity, and is a sensitive marker of CYP 3A activity, especially to assess induction but also inhibition.
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Increased omeprazole metabolism in carriers of the CYP2C19*17 allele; a pharmacokinetic study in healthy volunteers

R. Michael Baldwin, +6 more
- 01 May 2008 - 
TL;DR: The observed differences in omeprazole AUC(infinity) suggest that the CYP2C19*17 allele is an important explanatory factor behind individual cases of therapeutic failure, and may be associated with subtherapeutic drug exposure.
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Carbamazepine metabolism in man. Induction and pharmacogenetic aspects.

Michel Eichelbaum, +3 more
- 01 Jan 1985 - 
TL;DR: The hydration of CBZ-E during carbamazepine therapy was found to be induced, but to a lesser extent than the epoxidation of carbazepine, and only a minor part of the 9-OH-CBZ excreted in urine duringcarbamazepines therapy is formed via the epoxide-diol pathway.
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Disposition of perphenazine is related to polymorphic debrisoquin hydroxylation in luman beings

Marja-Liisa Dahl-Puustinen, +9 more
- 01 Jul 1989 - 
TL;DR: The pharmacokinetics of a single oral dose of 6 mg perphenazine was studied in a group of six slow and six rapid hydroxylators of debrisoquin and the data suggest that the disposition of the antipsychotic drug per phenazine covaries with polymorphic debrisOquin hydroxymation.