L
Leif Bertilsson
Researcher at Karolinska University Hospital
Publications - 321
Citations - 24620
Leif Bertilsson is an academic researcher from Karolinska University Hospital. The author has contributed to research in topics: Debrisoquine & Debrisoquin. The author has an hindex of 87, co-authored 321 publications receiving 23933 citations. Previous affiliations of Leif Bertilsson include Astra & University of Oulu.
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Journal ArticleDOI
Prevalence and risk factors for efavirenz-based antiretroviral treatment-associated severe vitamin D deficiency: A prospective cohort study.
Hanna Nylén,Abiy Habtewold,Eyasu Makonnen,Getnet Yimer,Leif Bertilsson,Jürgen Burhenne,Ulf Diczfalusy,Eleni Aklillu +7 more
TL;DR: Low plasma cholesterol, high CYP3A activity, and high plasma efavirenz concentrations as significant predictors of early ef Cavirenz-based cART-induced vitamin D deficiency are indicated.
Journal ArticleDOI
Fluconazole-induced intoxication with phenytoin in a patient with ultra-high activity of CYP2C9.
Anders Helldén,Ulf Bergman,Karin Hellgren,Michèle Masquelier,Ingela Nilsson Remahl,Ingegerd Odar-Cederlöf,Margareta Ramsjö,Leif Bertilsson +7 more
TL;DR: The finding of an ultrarapid metabolism of losartan and phenytoin may apply to other CYP2C9 substrates, where inhibition of CYP 2C9 may cause severe adverse drug reactions.
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Inflammation down-regulates CYP3A4-catalysed drug metabolism in hemodialysis patients
Hadi Molanaei,Abdul Rashid Qureshi,Olof Heimbürger,Bengt Lindholm,Ulf Diczfalusy,Björn Anderstam,Leif Bertilsson,Peter Stenvinkel +7 more
TL;DR: The association between CYP3A4 activity and inflammatory biomarkers suggest that the activity of CYP2A4 is reduced by inflammation in HD patients, and further studies are needed to confirm this finding.
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Long-Term Effect of Rifampicin-Based Anti-TB Regimen Coadministration on the Pharmacokinetic Parameters of Efavirenz and 8-Hydroxy-Efavirenz in Ethiopian Patients
Abiy Habtewold,Abiy Habtewold,Abiy Habtewold,Eleni Aklillu,Eyasu Makonnen,Wondwossen Amogne,Getnet Yimer,Getachew Aderaye,Leif Bertilsson,Joel S. Owen,Jürgen Burhenne +10 more
TL;DR: Higher exposure to 8‐OH‐EFV during simultaneous coadministration of EFV and RIF‐based anti‐TB regimens, which may be associated with neurotoxicity, is called for, particularly in female patients and CYP2B6*6 carriers.
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Nortriptyline formation after single oral and intramuscular doses of amitriptyline.
B. Mellstrom,B. Mellstrom,G. Alvan,G. Alvan,Leif Bertilsson,Leif Bertilsson,William Z. Potter,William Z. Potter,J. Sawe,J. Sawe,Folke Sjöqvist,Folke Sjöqvist +11 more
TL;DR: The area under the plasma concentration‐time curve (AUC) for nortriptyline formed was calculated and there was no difference between the AUCs (corrected for dose) after the two routes of administration.