L
Leif Bertilsson
Researcher at Karolinska University Hospital
Publications - 321
Citations - 24620
Leif Bertilsson is an academic researcher from Karolinska University Hospital. The author has contributed to research in topics: Debrisoquine & Debrisoquin. The author has an hindex of 87, co-authored 321 publications receiving 23933 citations. Previous affiliations of Leif Bertilsson include Astra & University of Oulu.
Papers
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Detection of N-terminally extended substance P but not of substance P in human cerebrospinal fluid: quantitation with HPLC-radioimmunoassay.
TL;DR: Results suggest that an N‐terminally extended form of SP is present in human CSF, and may indicate that N‐Terminal fragments of SP extended at the N‐ terminus or SP molecules extended at both the N and the C‐terminus also are present inhuman CSF.
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Inhibition of CYP3A4 and CYP3A5 catalyzed metabolism of alprazolam and quinine by ketoconazole as racemate and four different enantiomers
TL;DR: KTZ racemate and enantiomers showed differential inhibitory effects of quinine and alprazolam metabolism, indicating that structural differences among the enantiomer would be related to their inhibitory potency on these two enzymes.
Journal Article
CSF monoamine metabolites, depression, and suicide
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Why are diazepam metabolism and polymorphic s-mephenytoin hydroxylation associated with each other in white and korean populations but not in chinese populations ?
Leif Bertilsson,Werner Kalow +1 more
TL;DR: Clinical Pharmacology and Therapeutics (1993) 53, 608–610; doi:10.1038/clpt.1993.77
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Severe adverse effects in a newborn with two defective CYP2D6 alleles after exposure to paroxetine during late pregnancy.
TL;DR: It is suggested that even low plasma concentrations of paroxetine may be related to perinatal complications in infants exposed to paroxETine during late pregnancy and that the poor metabolizer genotype of CYP2D6 may be a risk factor for these complications.