L
Leif Bertilsson
Researcher at Karolinska University Hospital
Publications - 321
Citations - 24620
Leif Bertilsson is an academic researcher from Karolinska University Hospital. The author has contributed to research in topics: Debrisoquine & Debrisoquin. The author has an hindex of 87, co-authored 321 publications receiving 23933 citations. Previous affiliations of Leif Bertilsson include Astra & University of Oulu.
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Journal ArticleDOI
Plasma concentrations of haloperidol are related to CYP2D6 genotype at low, but not high doses of haloperidol in Korean schizophrenic patients.
Hyung-Keun Roh,Hyung-Keun Roh,Jea-Yon Chung,Dong-Yul Oh,Chang-Shin Park,Jan-Olof Svensson,Marja-Liisa Dahl,Leif Bertilsson +7 more
TL;DR: The involvement of CYP2D6 in the metabolism of haloperidol at low doses of hal operidol (< 20 mg daily), while another enzyme, probably CYP3A4, contributes at higher doses is suggested.
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Effects of caffeine intake on the pharmacokinetics of melatonin, a probe drug for CYP1A2 activity.
Sebastian Härtter,Anna Nordmark,Dirk-Matthias Rose,Leif Bertilsson,Gunnel Tybring,Kari Laine +5 more
TL;DR: A pronounced effect of caffeine on the bioavailability of orally given melatonin is revealed, most probably due to inhibition of CYP1A2 activity.
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Comparison of Endogenous 4β-hydroxycholesterol with Midazolam as Markers for CYP3A4 Induction by Rifampicin
Linda Björkhem-Bergman,Tobias Bäckström,Hanna Nylén,Yuko Rönquist-Nii,Eva Bredberg,Tommy B. Andersson,Leif Bertilsson,Ulf Diczfalusy +7 more
TL;DR: The 4β-hydroxycholesterol ratio is comparable to midazolam clearance as a marker of CYP3A4 induction, and each may be used to evaluate CYP 3A4 induction in clinical trials evaluating drug-drug interactions for new drugs.
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Plasma concentrations of nortriptyline and its 10-hydroxy metabolite in depressed patients--relationship to the debrisoquine hydroxylation metabolic ratio.
TL;DR: In 20 depressed patients treated with nortriptyline (NT) there was a significant relationship between the plasma concentration of NT and the debrisoquine metabolic ratio (rs = 0.77; P less than 0.01), in agreement with the hypothesis that the hydroxylations ofNT and debrisquine are mediated by similar enzymatic mechanisms.
Journal ArticleDOI
Kinetics of omeprazole and escitalopram in relation to the CYP2C19*17 allele in healthy subjects.
Staffan Rosenborg,Jessica Mwinyi,Maria Andersson,R. Michael Baldwin,Rasmus Steen Pedersen,Sarah C. Sim,Leif Bertilsson,Magnus Ingelman-Sundberg,Erik Eliasson +8 more
TL;DR: It is concluded that a clinically significant difference in escitalopram or omeprazole kinetics between the genotypes appears unlikely.