Lena Morrill Gavarró

TL;DR: The wide-ranging biomedical utilities of PLC-derived organoid models in furthering the understanding of liver cancer biology and in developing personalized-medicine approaches for the disease are demonstrated.

TL;DR: It is demonstrated that the tumor–immune microenvironment of advanced HGSOC is intrinsically heterogeneous and that chemotherapy induces local immune activation, suggesting that chemotherapy can potentiate the immunogenicity of immune-excluded H GSOC tumors.

TL;DR: In this article, the authors performed shallow whole genome sequencing (sWGS) and targeted next generation sequencing to investigate somatic mutations and copy number alterations in early stage serous carcinoma (HGSC).

TL;DR: It is identified that early stage and late stage HGSC have highly similar patterns of mutation and focal SCNA, and genome-wide analysis indicates that the abnormalities seen in advanced disease are not present in early stage disease, which may represent a discrete subset with reduced metastatic potential.