L
Leo E. Otterbein
Researcher at Beth Israel Deaconess Medical Center
Publications - 228
Citations - 24913
Leo E. Otterbein is an academic researcher from Beth Israel Deaconess Medical Center. The author has contributed to research in topics: Heme oxygenase & Heme. The author has an hindex of 79, co-authored 221 publications receiving 22713 citations. Previous affiliations of Leo E. Otterbein include Veterans Health Administration & Johns Hopkins University School of Medicine.
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Journal ArticleDOI
Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway
Leo E. Otterbein,Leo E. Otterbein,Fritz H. Bach,Jawed Alam,Miguel P. Soares,Hong-Tao Lu,Mark Allen Wysk,Roger J. Davis,Richard A. Flavell,Augustine M.K. Choi,Augustine M.K. Choi +10 more
TL;DR: It is demonstrated here that carbon monoxide, a by-product of heme catabolism by heme oxygenase, mediates potent anti-inflammatory effects and may have an important protective function in inflammatory disease states and thus has potential therapeutic uses.
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The therapeutic potential of carbon monoxide.
TL;DR: An overview of the physiology of CO is provided, the effects of CO gas and CO-releasing molecules in preclinical animal models of cardiovascular disease, inflammatory disorders and organ transplantation are summarized, and the development and therapeutic options for the exploitation of this simple gaseous molecule are discussed.
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Heme oxygenase-1: unleashing the protective properties of heme
TL;DR: It is suggested that the products of HO-1 action could be valuable therapeutic agents and speculate thatHO-1 functions as a "therapeutic funnel", mediating the beneficial effects attributed to other molecules, such as interleukin-10 (IL-10), inducible nitric oxide synthase (NOS2; iNOS) and prostaglandins.
Journal ArticleDOI
Carbon monoxide generated by heme oxygenase 1 suppresses endothelial cell apoptosis.
Sophie Brouard,Leo E. Otterbein,Josef Anrather,Edda Tobiasch,Fritz H. Bach,Augustine M.K. Choi,Miguel P. Soares +6 more
TL;DR: The data demonstrate that the antiapoptotic effect of HO-1 in ECs is mediated by CO and more specifically via the activation of p38 MAPK by CO.
Journal ArticleDOI
Heme oxygenase: colors of defense against cellular stress
TL;DR: The functional role of HO in lung biology and its real potential application to lung diseases is reviewed.