L
Leonard Guarente
Researcher at Massachusetts Institute of Technology
Publications - 353
Citations - 86116
Leonard Guarente is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Gene & Saccharomyces cerevisiae. The author has an hindex of 143, co-authored 352 publications receiving 80169 citations. Previous affiliations of Leonard Guarente include Novartis & Harvard University.
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Journal ArticleDOI
A yeast and a human CCAAT-binding protein have heterologous subunits that are functionally interchangeable
Lewis A. Chodosh,James Olesen,Steven Hahn,Albert S. Baldwin,Albert S. Baldwin,Leonard Guarente,Phillip A. Sharp,Phillip A. Sharp +7 more
TL;DR: Notably, the subunits of CP1 and HAP2/HAP3 are functionally interchangeable, which means that the yeast/human hybrid complexes that are formed retain the ability to specifically recognize CCAAT elements.
Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells
Sarah-Maria Fendt,Eric L. Bell,Mark A. Keibler,Benjamin A. Olenchock,Benjamin A. Olenchock,Benjamin A. Olenchock,Jared R. Mayers,Thomas M. Wasylenko,Natalie I. Vokes,Leonard Guarente,Matthew G. Vander Heiden,Matthew G. Vander Heiden,Gregory Stephanopoulos +12 more
TL;DR: The authors identify several cellular conditions where the α-ketoglutarate/citrate ratio is changed due to an altered acetyl-CoA to citrate conversion, and demonstrate that reductive glutamine metabolism is initiated in response to perturbations that result in an increase in the α −ketoglUTarate/ citrate ratio.
Journal ArticleDOI
mTORC1 and SIRT1 Cooperate to Foster Expansion of Gut Adult Stem Cells during Calorie Restriction.
Masaki Igarashi,Leonard Guarente +1 more
TL;DR: It is suggested that Paneth cell signaling overrides any direct nutrient sensing in ISCs to sculpt the observed response to CR, and drugs that modulate pathways important in CR may exert opposing effects on different cell types.
Journal ArticleDOI
Nucleolar localization of the Werner syndrome protein in human cells
TL;DR: The nucleolar localization of human WRN protein was supported by the finding that upon biochemical subcellular fractionation, WRNprotein is present in an increased concentration in a subnuclear fraction enriched for nucleolar proteins.
Journal ArticleDOI
SIRT1 Activates MAO-A in the Brain to Mediate Anxiety and Exploratory Drive
Sergiy Libert,Kelli B. Pointer,Eric L. Bell,Abhirup Das,Dena E. Cohen,Dena E. Cohen,John M. Asara,Karen Kapur,Sven Bergmann,Martin Preisig,Takeshi Otowa,Kenneth S. Kendler,Xiangning Chen,John M. Hettema,Edwin J. C. G. van den Oord,Justin P. Rubio,Leonard Guarente +16 more
TL;DR: Treating animals with MAO-A inhibitors or selective serotonin reuptake inhibitors (SSRIs) normalized anxiety differences between wild-type and mutant animals, indicating that SIRT1 mediates levels of anxiety, and this regulation may be adaptive in a changing environment of food availability.