L
Leonard M. G. Chavas
Researcher at KEK
Publications - 46
Citations - 928
Leonard M. G. Chavas is an academic researcher from KEK. The author has contributed to research in topics: Beamline & Protein crystallization. The author has an hindex of 15, co-authored 40 publications receiving 761 citations. Previous affiliations of Leonard M. G. Chavas include University of Manchester & Mexican Social Security Institute.
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Journal ArticleDOI
Crystal Structure of the Human Cytosolic Sialidase Neu2: EVIDENCE FOR THE DYNAMIC NATURE OF SUBSTRATE RECOGNITION
Leonard M. G. Chavas,Leonard M. G. Chavas,Cristina Tringali,Paola Fusi,Bruno Venerando,Guido Tettamanti,Ryuichi Kato,Ryuichi Kato,Eugenio Monti,Soichi Wakatsuki,Soichi Wakatsuki +10 more
TL;DR: The first high resolution x-ray structures of mammalian sialidase, human Neu2, in its apo form and in complex with an inhibitor, 2-deoxy-2,3-dehydro-N-acetylneuraminic acid (DANA), are reported.
Journal ArticleDOI
Complexity in influenza virus targeted drug design: interaction with human sialidases.
Leonard M. G. Chavas,Ryuichi Kato,Nobuhiro Suzuki,Mark von Itzstein,Maretta Mann,Robin J. Thomson,Jeffrey Clifford Dyason,Jennifer L. McKimm-Breschkin,Paola Fusi,Cristina Tringali,Bruno Venerando,Guido Tettamanti,Eugenio Monti,Soichi Wakatsuki +13 more
TL;DR: Structural and biochemical studies of the human cytosolic sialidase Neu2 with influenza virus sIALidase-targeting drugs and related compounds are reported.
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Development of an automated large-scale protein-crystallization and monitoring system for high-throughput protein-structure analyses
Masahiko Hiraki,Ryuichi Kato,Minoru Nagai,Tadashi Satoh,Satoshi Hirano,Kentaro Ihara,Norio Kudo,Masamichi Nagae,Masanori Kobayashi,Michio Inoue,Tamami Uejima,Shunichiro Oda,Leonard M. G. Chavas,Masato Akutsu,Yusuke Yamada,Masato Kawasaki,Naohiro Matsugaki,Noriyuki Igarashi,Mamoru Suzuki,Soichi Wakatsuki +19 more
TL;DR: An automated large-scale protein-crystallization system named PXS has been developed consisting of the following subsystems, which proceed in parallel under unified control software: dispensing precipitants and protein solutions, sealing crystallization plates, carrying robot, incubators, observation system and image-storage server.
Journal ArticleDOI
Elucidation of Rab27 recruitment by its effectors: structure of Rab27a bound to Exophilin4/Slp2-a.
Leonard M. G. Chavas,Kentaro Ihara,Masato Kawasaki,Seiji Torii,Tamami Uejima,Ryuichi Kato,Tetsuro Izumi,Soichi Wakatsuki +7 more
TL;DR: The observed structural complementation between the interacting surfaces of Rab27a and Exophilin4 sheds light on the disparities among the Rab27 effectors and outlines a general mechanism for their recruitment.
Journal ArticleDOI
Crystal structure of the catalytic domain of the mitotic checkpoint kinase Mps1 in complex with SP600125.
Matthew Ling-Hon Chu,Leonard M. G. Chavas,Kenneth T. Douglas,Patrick A. Eyers,Lydia Tabernero +4 more
TL;DR: The x-ray structure of Monopolar spindle 1 is determined, both alone and in complex with the ATP-competitive inhibitor SP600125, which provides important insights into the interaction of this protein kinase with small molecules and suggest potential mechanisms for Mps1 regulation.