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Andrew M. Donson
Researcher at Anschutz Medical Campus
Publications - 139
Citations - 6568
Andrew M. Donson is an academic researcher from Anschutz Medical Campus. The author has contributed to research in topics: Medicine & Medulloblastoma. The author has an hindex of 34, co-authored 110 publications receiving 5175 citations. Previous affiliations of Andrew M. Donson include University of Melbourne & Boston Children's Hospital.
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Journal ArticleDOI
Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma.
Dominik Sturm,Hendrik Witt,Hendrik Witt,Volker Hovestadt,Dong Anh Khuong-Quang,David T.W. Jones,Carolin Konermann,Elke Pfaff,Martje Tönjes,Martin Sill,Sebastian Bender,Marcel Kool,Marc Zapatka,Natalia Becker,Manuela Zucknick,Thomas Hielscher,Xiaoyang Liu,Adam M. Fontebasso,Marina Ryzhova,Steffen Albrecht,Karine Jacob,Marietta Wolter,Martin Ebinger,Martin U. Schuhmann,Timothy E. Van Meter,Michael C. Frühwald,Holger Hauch,Arnulf Pekrun,Bernhard Radlwimmer,Tim Niehues,Gregor Von Komorowski,Matthias Dürken,Andreas E. Kulozik,Jenny Madden,Andrew M. Donson,Nicholas K. Foreman,Rachid Drissi,Maryam Fouladi,Wolfram Scheurlen,Andreas von Deimling,Andreas von Deimling,Camelia M. Monoranu,Wolfgang Roggendorf,Christel Herold-Mende,Andreas Unterberg,Christof M. Kramm,Jörg Felsberg,Christian Hartmann,Benedikt Wiestler,Wolfgang Wick,Till Milde,Till Milde,Olaf Witt,Olaf Witt,Anders Lindroth,Jeremy Schwartzentruber,Damien Faury,Adam Fleming,Magdalena Zakrzewska,Pawel P. Liberski,Krzysztof Zakrzewski,Peter Hauser,Miklós Garami,Almos Klekner,László Bognár,Sorana Morrissy,Florence M.G. Cavalli,Michael D. Taylor,Peter van Sluis,Jan Koster,Rogier Versteeg,Richard Volckmann,Tom Mikkelsen,Kenneth Aldape,Guido Reifenberger,V. Peter Collins,Jacek Majewski,Andrey Korshunov,Peter Lichter,Christoph Plass,Nada Jabado,Stefan M. Pfister,Stefan M. Pfister +82 more
TL;DR: It is demonstrated that each H3F3A mutation defines an epigenetic subgroup of GBM with a distinct global methylation pattern, and that they are mutually exclusive with IDH1 mutations, which characterize a third mutation-defined subgroup.
Journal ArticleDOI
Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups
Kristian W. Pajtler,Kristian W. Pajtler,Hendrik Witt,Martin Sill,David T.W. Jones,Volker Hovestadt,Fabian Kratochwil,Khalida Wani,Ruth G. Tatevossian,Chandanamali Punchihewa,Pascal Johann,Jüri Reimand,Hans-Jörg Warnatz,Marina Ryzhova,Steve Mack,Vijay Ramaswamy,David Capper,David Capper,Leonille Schweizer,Leonille Schweizer,Laura Sieber,Andrea Wittmann,Zhiqin Huang,Peter van Sluis,Richard Volckmann,Jan Koster,Rogier Versteeg,Daniel W. Fults,Helen Toledano,Smadar Avigad,Lindsey M. Hoffman,Andrew M. Donson,Nicholas K. Foreman,Ekkehard Hewer,Karel Zitterbart,Mark R. Gilbert,Terri S. Armstrong,Terri S. Armstrong,Nalin Gupta,Jeffrey C. Allen,Matthias A. Karajannis,David Zagzag,Martin Hasselblatt,Andreas E. Kulozik,Olaf Witt,V. Peter Collins,Katja von Hoff,Stefan Rutkowski,Torsten Pietsch,Gary D. Bader,Marie-Laure Yaspo,Andreas von Deimling,Andreas von Deimling,Peter Lichter,Michael D. Taylor,Richard J. Gilbertson,David W. Ellison,Kenneth Aldape,Andrey Korshunov,Andrey Korshunov,Marcel Kool,Stefan M. Pfister +61 more
TL;DR: The molecular classification proposed herein outperforms the current histopathological classification and thus might serve as a basis for the next World Health Organization classification of CNS tumors.
Journal ArticleDOI
Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations
Pawel Buczkowicz,Christine M. Hoeman,Patricia Rakopoulos,Sanja Pajovic,Louis Letourneau,Misko Dzamba,Andrew Morrison,Peter W. Lewis,Eric Bouffet,Ute Bartels,Jennifer Zuccaro,Sameer Agnihotri,Scott Ryall,Mark Barszczyk,Yevgen Chornenkyy,Mathieu Bourgey,Guillaume Bourque,Alexandre Montpetit,Francisco Cordero,Pedro Castelo-Branco,Joshua Mangerel,Uri Tabori,King Ching Ho,Annie Huang,Kathryn R. Taylor,Alan Mackay,Anne Bendel,Javad Nazarian,Jason Fangusaro,Matthias A. Karajannis,David Zagzag,Nicholas K. Foreman,Andrew M. Donson,Julia V Hegert,Amy Smith,Jennifer A. Chan,Lucy Lafay-Cousin,Sandra E. Dunn,Juliette Hukin,Chris Dunham,Katrin Scheinemann,Jean Michaud,Shayna Zelcer,David A. Ramsay,Jason E. Cain,Cameron Brennan,Mark M. Souweidane,Chris Jones,C. David Allis,Michael Brudno,Michael Brudno,Oren J. Becher,Cynthia Hawkins +52 more
TL;DR: This work integrated whole-genome sequencing with methylation, expression and copy number profiling, discovering that DIPGs comprise three molecularly distinct subgroups (H3-K27M, silent and MYCN) and uncovering a new recurrent activating mutation affecting the activin receptor gene ACVR1 in 20% of DIPG.
Journal ArticleDOI
Autophagy inhibition improves chemosensitivity in BRAF(V600E) brain tumors.
Jean M. Mulcahy Levy,Joshua C. Thompson,Andrea Griesinger,Vladimir Amani,Andrew M. Donson,Diane K. Birks,Michael J. Morgan,David M. Mirsky,Michael H. Handler,Nicholas K. Foreman,Andrew Thorburn +10 more
TL;DR: In this article, the authors found that mutant cells with BRAFV600E exhibited high rates of induced autophagy, are sensitive to pharmacologic and genetic autophagation inhibition, and display synergy when combined with the Raf inhibitor vemurafenib or standard chemotherapeutics.
Journal ArticleDOI
MGMT promoter methylation correlates with survival benefit and sensitivity to temozolomide in pediatric glioblastoma
TL;DR: This data indicates that methylation of the DNA‐repair gene O6‐methylguanine‐DNA methyltransferase causes gene silencing in children with GBM and its relationship to survival and temozolomide sensitivity is unclear.