L
Lesley A. Wilson
Researcher at University of Leeds
Publications - 9
Citations - 1137
Lesley A. Wilson is an academic researcher from University of Leeds. The author has contributed to research in topics: TRPC5 & Transient receptor potential channel. The author has an hindex of 8, co-authored 9 publications receiving 895 citations.
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Journal ArticleDOI
Piezo1 integration of vascular architecture with physiological force
Jing Li,Bing Hou,Sarka Tumova,Katsuhiko Muraki,Alexander F. Bruns,Melanie J. Ludlow,Alicia Sedo,Adam J. Hyman,Lynn McKeown,Richard S. Young,Richard S. Young,Nadira Yuldasheva,Yasser Majeed,Lesley A. Wilson,Baptiste Rode,Marc A. Bailey,Hyejeong R. Kim,Zhaojun Fu,Deborah Angela Louise Carter,Jan Bilton,Helen Imrie,Paul Ajuh,T. Neil Dear,Richard M Cubbon,Mark T. Kearney,K. Raj Prasad,Paul C. Evans,Justin F. X. Ainscough,David J. Beech +28 more
TL;DR: Piezo1 channels are shown as sensors of frictional force (shear stress) and determinants of vascular structure in both development and adult physiology and the data suggest that Piezo 1 channels function as pivotal integrators in vascular biology.
Journal ArticleDOI
Orai1 and CRAC Channel Dependence of VEGF-Activated Ca2+ Entry and Endothelial Tube Formation
Jing Li,Richard M Cubbon,Lesley A. Wilson,Mohamed S Amer,Mohamed S Amer,Lynn McKeown,Bing Hou,Yasser Majeed,Sarka Tumova,Victoria A.L. Seymour,Hilary Taylor,Martin Stacey,David J. O'Regan,Richard Foster,Karen E. Porter,Mark T. Kearney,David J. Beech +16 more
TL;DR: Positive roles for Orai1 and CRAC channels in VEGF-evoked calcium entry and new opportunity for chemical modulation of angiogenesis are suggested.
Journal ArticleDOI
Constitutively Active TRPC Channels of Adipocytes Confer a Mechanism for Sensing Dietary Fatty Acids and Regulating Adiponectin
Piruthivi Sukumar,Alicia Sedo,Jing Li,Lesley A. Wilson,David J. O'Regan,Jonathan D. Lippiat,Karen E. Porter,Mark T. Kearney,Justin F. X. Ainscough,David J. Beech +9 more
TL;DR: The data suggest that TRPC1 and TRPC5 contribute a constitutively active heteromultimeric channel of adipocytes that negatively regulates adiponectin and through which &ohgr;-3 fatty acids enhance the anti-inflammatory adipokine, adiponECTin.
Journal ArticleDOI
Rapid and Contrasting Effects of Rosiglitazone on Transient Receptor Potential TRPM3 and TRPC5 Channels
Yasser Majeed,Yahya M Bahnasi,Victoria A.L. Seymour,Lesley A. Wilson,Carol J. Milligan,Anil Agarwal,Piruthivi Sukumar,Jacqueline Naylor,David J. Beech +8 more
TL;DR: The data suggest that rosiglitazone contains chemical moieties that rapidly, strongly, and differentially modulate TRP channels independently of PPAR-γ, potentially contributing to biological consequences of the agent and providing the basis for novel TRP channel pharmacology.
Journal ArticleDOI
Inhibition of endothelial cell Ca2+ entry and transient receptor potential channels by Sigma‐1 receptor ligands
Mohamed S Amer,Lynn McKeown,Sarka Tumova,Ruifeng Liu,Victoria A.L. Seymour,Lesley A. Wilson,Jacqueline Naylor,Katriona Greenhalgh,Bing Hou,Yasser Majeed,Paul Turner,Alicia Sedo,David J. O'Regan,Jing Li,Robin S. Bon,Karen E. Porter,David J. Beech +16 more
TL;DR: This study investigated Sig1R and its ligands in relation to endogenous calcium events of endothelial cells and transient receptor potential (TRP) channels.