T
T. Neil Dear
Researcher at University of Leeds
Publications - 4
Citations - 1120
T. Neil Dear is an academic researcher from University of Leeds. The author has contributed to research in topics: Angiogenesis & Voltage-dependent calcium channel. The author has an hindex of 4, co-authored 4 publications receiving 846 citations.
Papers
More filters
Journal ArticleDOI
Piezo1 integration of vascular architecture with physiological force
Jing Li,Bing Hou,Sarka Tumova,Katsuhiko Muraki,Alexander F. Bruns,Melanie J. Ludlow,Alicia Sedo,Adam J. Hyman,Lynn McKeown,Richard S. Young,Richard S. Young,Nadira Yuldasheva,Yasser Majeed,Lesley A. Wilson,Baptiste Rode,Marc A. Bailey,Hyejeong R. Kim,Zhaojun Fu,Deborah Angela Louise Carter,Jan Bilton,Helen Imrie,Paul Ajuh,T. Neil Dear,Richard M Cubbon,Mark T. Kearney,K. Raj Prasad,Paul C. Evans,Justin F. X. Ainscough,David J. Beech +28 more
TL;DR: Piezo1 channels are shown as sensors of frictional force (shear stress) and determinants of vascular structure in both development and adult physiology and the data suggest that Piezo 1 channels function as pivotal integrators in vascular biology.
Journal ArticleDOI
Osteoclasts control reactivation of dormant myeloma cells by remodelling the endosteal niche.
Michelle A. Lawson,Michelle M. McDonald,Michelle M. McDonald,Nataša Kovačić,Weng Hua Khoo,Weng Hua Khoo,Rachael L. Terry,Rachael L. Terry,Jenny Down,Warren Kaplan,Warren Kaplan,Julia Paton-Hough,Clair Fellows,Jessica A. Pettitt,T. Neil Dear,Els Van Valckenborgh,Paul A. Baldock,Paul A. Baldock,Michael J. Rogers,Michael J. Rogers,Colby L. Eaton,Karin Vanderkerken,Allison R. Pettit,Julian M.W. Quinn,Andrew C.W. Zannettino,Tri Giang Phan,Tri Giang Phan,Peter I. Croucher,Peter I. Croucher +28 more
TL;DR: It is demonstrated that dormancy is a reversible state that is switched 'on' by engagement with bone-lining cells or osteoblasts, and switched ‘off' by osteoclasts remodelling the endosteal niche.
Journal ArticleDOI
Glycine Receptor α2 Subunit Activation Promotes Cortical Interneuron Migration
TL;DR: It is discovered that extrasynaptic activation of GlyRs containing the α2 subunit in cortical interneurons by endogenous glycine activates voltage-gated calcium channels and promotes calcium influx, which further modulates actomyosin contractility to fine-tune nuclear translocation during migration.
Journal ArticleDOI
A Rac/Cdc42 exchange factor complex promotes formation of lateral filopodia and blood vessel lumen morphogenesis
Sabu Abraham,Margherita Scarcia,Richard D. Bagshaw,Kathryn McMahon,Gary Grant,Tracey J. Harvey,Maggie Yeo,Filomena Esteves,Helene Thygesen,Pamela F. Jones,Valerie Speirs,Andrew M. Hanby,Peter Selby,Mihaela Lorger,T. Neil Dear,Tony Pawson,Christopher J. Marshall,Georgia Mavria +17 more
TL;DR: These studies identify a novel Rho-family GTPase activation cascade for the formation of endothelial cell filopodial protrusions necessary for tubule remodelling, thereby influencing subsequent stages of lumen morphogenesis.