L
Lesley Hoyles
Researcher at Nottingham Trent University
Publications - 120
Citations - 8449
Lesley Hoyles is an academic researcher from Nottingham Trent University. The author has contributed to research in topics: Microbiome & Medicine. The author has an hindex of 28, co-authored 102 publications receiving 6232 citations. Previous affiliations of Lesley Hoyles include University of Reading & University of Westminster.
Papers
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Posted ContentDOI
Microbiome inhibition of IRAK-4 by trimethylamine mediates metabolic and immune benefits in high-fat-diet-induced insulin resistance
Julien Chilloux,Francois Brial,Amandine Everard,David Smyth,Liyong Zhang,Hubert Plovier,Antonis Myridakis,Lesley Hoyles,Julian E. Fuchs,Christine Blancher,Selin Gencer,Laura Martinez-Gili,Jane F. Fearnside,Richard H. Barton,Ana Luisa Neves,Alice R. Rothwell,Christelle C. Gérard,Sophie Calderari,Claire L. Boulangé,Saroor A. A. Patel,James Scott,Robert C. Glen,Robert C. Glen,Nigel J. Gooderham,Jeremy K. Nicholson,Dominique Gauguier,Peter P. Liu,Patrice D. Cani,Patrice D. Cani,Marc-Emmanuel Dumas +29 more
TL;DR: TMA appears as a key microbial effector inhibiting IRAK-4 and mediating metabolic and immune effects with benefits upon HFD, highlighting the critical contribution of the microbial signalling metabolome in homeostatic regulation of host disease and the emerging role of the kinome6 in microbial–mammalian chemical crosstalk.
Journal Article
Arcanobacterium/Corynebacterium - like bacterial isolates from sheep
Posted ContentDOI
Faecal microbiota transplant from aged donor mice into young recipients affects spatial learning and memory
Alfonsina D'Amato,Lorenzo Di Cesare-Mannelli,Elena Lucarini,Angela L. Man,Gwénaëlle Le Gall,Jacopo Junio Valerio Branca,Carla Ghelardini,Amedeo Amedei,Eugenio Bertelli,Marì Regoli,Alessandra Pacini,Giulia Luciani,Pasquale Gallina,Annalisa Altera,Arjan Narbad,Massimo Gulisano,Lesley Hoyles,David Vauzour,Claudio Nicoletti +18 more
TL;DR: It is concluded that the age-associated alteration of the gut microbiota contributes to the decline of key functions of the CNS through the modulation of hippocampal synaptic plasticity-related proteins.
Journal ArticleDOI
Kroppenstedtia pulmonis sp. nov. and Kroppenstedtia sanguinis sp. nov., isolated from human patients
Melissa Bell,Brent A. Lasker,Hans-Peter Klenk,Lesley Hoyles,Catherine Spröer,Peter Schumann,June M. Brown +6 more
TL;DR: Differences in endospore morphology, carbon source utilisation profiles, and cell wall sugar patterns of strains W9323T and X0209T, supported by phylogenetic analysis, enabled it to be concluded that the strains each represent a new species within the genus Kroppenstedtia.
Book ChapterDOI
Gastrointestinal Tract: Fat Metabolism in the Colon
Lesley Hoyles,Robert Wallace +1 more
TL;DR: Generally, only a small proportion of dietary fat that is consumed by man reaches the large intestine, and, increasingly, slimming drugs that inhibit pancreatic lipases or adsorbants that enable fat to bypass the small intestine also result in large quantities of dietary lipids reaching the colon.