L
Lesley Hoyles
Researcher at Nottingham Trent University
Publications - 120
Citations - 8449
Lesley Hoyles is an academic researcher from Nottingham Trent University. The author has contributed to research in topics: Microbiome & Medicine. The author has an hindex of 28, co-authored 102 publications receiving 6232 citations. Previous affiliations of Lesley Hoyles include University of Reading & University of Westminster.
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Journal ArticleDOI
Klebsiella pneumoniae subsp. pneumoniae-bacteriophage combination from the caecal effluent of a healthy woman.
Lesley Hoyles,Lesley Hoyles,James Murphy,Horst Neve,Knut J. Heller,J.F. Turton,Jennifer Mahony,Jeremy D. Sanderson,B. Hudspith,Glenn R. Gibson,Anne L. McCartney,D. van Sinderen +11 more
TL;DR: A sample of caecal effluent was obtained from a female patient who had undergone a routine colonoscopic examination and phages KLPN1 and 1513 were found to be two new members of the genus “Kp36likevirus”.
Journal ArticleDOI
Iron status influences non-alcoholic fatty liver disease in obesity through the gut microbiome
Jordi Mayneris-Perxachs,Jordi Mayneris-Perxachs,Marina Cardellini,Lesley Hoyles,Lesley Hoyles,Jèssica Latorre,Jèssica Latorre,Francesca Davato,José María Moreno-Navarrete,José María Moreno-Navarrete,María Arnoriaga-Rodríguez,María Arnoriaga-Rodríguez,Matteo Serino,Matteo Serino,James Abbott,Richard H. Barton,Josep Puig,Josep Puig,Xavier Fernández-Real,Wifredo Ricart,Wifredo Ricart,Christopher Tomlinson,Mark Woodbridge,Paolo Gentileschi,Sarah Butcher,Elaine Holmes,Jeremy K. Nicholson,Vicente Pérez-Brocal,Andrés Moya,Donald Mc Clain,Donald Mc Clain,Rémy Burcelin,Rémy Burcelin,Marc-Emmanuel Dumas,Massimo Federici,José Manuel Fernández-Real,José Manuel Fernández-Real +36 more
TL;DR: In this paper, the authors applied an integrative system medicine approach (faecal metagenomics, plasma and urine metabolomics, hepatic transcriptomics) in 2 well-characterised human cohorts of subjects with obesity (discovery n = 49 and validation n = 628) and an independent cohort formed by both individuals with and without obesity (n = 130), combined with in vitro and animal models.
Journal ArticleDOI
Characterization of Actinomyces isolates from samples from the human urogenital tract: description of Actinomyces urogenitalis sp. nov.
TL;DR: It is proposed that the unknown bacterium from humans be classified as Actinomyces urogenitalis sp.
Journal ArticleDOI
Deficient Resident Memory T Cell and CD8 T Cell Response to Commensals in Inflammatory Bowel Disease.
Alistair Noble,Alistair Noble,Lydia Durant,Lesley Hoyles,Lesley Hoyles,Anne L. McCartney,Ripple Man,Jonathan Segal,Jonathan Segal,Samuel P Costello,P Hendy,P Hendy,Durga Reddi,Sonia Bouri,Dennis N. F. Lim,Toby Pring,Matthew J. O’Connor,Pooja Datt,Ana Wilson,Naila Arebi,Ayesha Akbar,Ailsa Hart,Ailsa Hart,Simon R. Carding,Simon R. Carding,Stella C. Knight,Stella C. Knight +26 more
TL;DR: Promoting Trm and their interaction with dendritic cells, rather than immunosuppression, may reinforce tissue immunity, improve barrier function, and prevent B cell dysfunction in microbiota-associated disease and IBD aetiology.
Posted ContentDOI
Regulation of blood-brain barrier integrity by microbiome-associated methylamines and cognition by trimethylamine N-oxide.
Lesley Hoyles,Matthew G. Pontifex,Ildefonso Rodríguez-Ramiro,Ildefonso Rodríguez-Ramiro,M. Areeb Anis-Alavi,Khadija S. Jelane,Tom Snelling,Egle Solito,Egle Solito,Sonia Fonseca,Ana L. Carvalho,Simon R. Carding,Simon R. Carding,Michael Müller,Robert C. Glen,Robert C. Glen,David Vauzour,Simon McArthur +17 more
TL;DR: In this article, the authors used an integrated in vitro/in vivo approach to show that physiologically relevant concentrations of the dietary methylamine trimethylamine N-oxide (TMAO) enhanced blood-brain barrier (BBB) integrity and protected it from inflammatory insult, acting through the tight junction regulator annexin A1.