L
Lesley Hoyles
Researcher at Nottingham Trent University
Publications - 120
Citations - 8449
Lesley Hoyles is an academic researcher from Nottingham Trent University. The author has contributed to research in topics: Microbiome & Medicine. The author has an hindex of 28, co-authored 102 publications receiving 6232 citations. Previous affiliations of Lesley Hoyles include University of Reading & University of Westminster.
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Regulation of blood-brain barrier integrity and cognition by the microbiome-associated methylamines trimethylamine N-oxide and trimethylamine
Lesley Hoyles,Matthew G. Pontifex,Ildefonso Rodríguez-Ramiro,Ildefonso Rodríguez-Ramiro,M. Areeb Anis-Alavi,Tom Snelling,Egle Solito,Egle Solito,Sonia Fonseca,Ana L. Carvalho,Simon R. Carding,Simon R. Carding,Michael Müller,Robert C. Glen,Robert C. Glen,David Vauzour,Simon McArthur +16 more
TL;DR: In this paper, an integrated in vitro/in vivo approach was used to show that physiologically relevant concentrations of the dietary methylamine trimethylamine N- oxide (TMAO) enhanced and protected blood-brain barrier (BBB) integrity, acting through the tight junction regulator annexin A1.
Journal ArticleDOI
A Data Integration Multi-Omics Approach to Study Calorie Restriction-Induced Changes in Insulin Sensitivity
Maria Carlota Dao,Nataliya Sokolovska,Rémi Brazeilles,Séverine Affeldt,Véronique Pelloux,Edi Prifti,Edi Prifti,Julien Chilloux,Eric O. Verger,Brandon D. Kayser,Judith Aron-Wisnewsky,Farid Ichou,Estelle Pujos-Guillot,Lesley Hoyles,Lesley Hoyles,Catherine Juste,Joël Doré,Marc-Emmanuel Dumas,Salwa W. Rizkalla,Bridget A. Holmes,Jean-Daniel Zucker,Jean-Daniel Zucker,Karine Clément +22 more
TL;DR: This work has enhanced previous knowledge on links between host glucose homeostasis, lifestyle factors and the gut microbiota, and has identified potential biomarkers that may be used in future studies to predict and improve individual response to weight-loss interventions.
Posted ContentDOI
Regulation of blood–brain barrier integrity by microbiome-associated methylamines and cognition by trimethylamine N-oxide
Lesley Hoyles,Matthew G. Pontifex,Ildefonso Rodríguez-Ramiro,Ildefonso Rodríguez-Ramiro,M. Areeb Anis-Alavi,Khadija S. Jelane,Tom Snelling,Egle Solito,Egle Solito,Sonia Fonseca,Ana L. Carvalho,Simon R. Carding,Simon R. Carding,Michael Müller,Robert C. Glen,Robert C. Glen,David Vauzour,Simon McArthur +17 more
TL;DR: In this paper, the authors used an integrated in vitro/in vivo approach to show that physiologically relevant concentrations of the dietary methylamine trimethylamine N-oxide (TMAO) enhanced blood-brain barrier (BBB) integrity and protected it from inflammatory insult, acting through the tight junction regulator annexin A1.
Journal ArticleDOI
Corynebacterium testudinoris sp. nov., from a tortoise, and Corynebacterium felinum sp. nov., from a Scottish wild cat
TL;DR: Two unknown gram-positive, rod-shaped bacteria isolated from a tortoise and a Scottish wild cat were subjected to a polyphasic taxonomic analysis and it was confirmed that the unknown isolates were members of the genus Corynebacterium.
Posted ContentDOI
Rapid MinION metagenomic profiling of the preterm infant gut microbiota to aid in pathogen diagnostics
Richard M. Leggett,Cristina Alcon-Giner,Darren Heavens,Shabhonam Caim,Thomas C. Brook,Magdalena Kujawska,Lesley Hoyles,Paul Clarke,Lindsay J. Hall,Matthew D. Clark +9 more
TL;DR: Data obtained revealed insights into how antibiotic treatment decisions may be rapidly modified in response to specific AMR profiles, which was validated using pathogen isolation, whole genome sequencing and antibiotic susceptibility testing.