L
Lesley Hoyles
Researcher at Nottingham Trent University
Publications - 120
Citations - 8449
Lesley Hoyles is an academic researcher from Nottingham Trent University. The author has contributed to research in topics: Microbiome & Medicine. The author has an hindex of 28, co-authored 102 publications receiving 6232 citations. Previous affiliations of Lesley Hoyles include University of Reading & University of Westminster.
Papers
More filters
Posted ContentDOI
An Integrated Workflow for Enhanced Taxonomic and Functional Coverage of the Mouse Faecal Metaproteome
Nicolas C. Nalpas,Lesley Hoyles,Lesley Hoyles,Viktoria Anselm,Tariq Ganief,Laura Martinez-Gili,Cristina Grau,Irina Droste-Borel,Laetitia Davidovic,Xavier Altafaj,Marc-Emmanuel Dumas,Marc-Emmanuel Dumas,Marc-Emmanuel Dumas,Boris Macek +13 more
TL;DR: It is shown that low speed centrifugation of faecal samples leads to high protein identification rates and a balanced taxonomic representation, and comparison of matching metaproteome and metagenome data revealed a positive correlation between protein and gene abundances, as well as significant overlap and correlation inTaxonomic representation.
Posted ContentDOI
Microbial–host metabolic systems interactions and the gut–brain axis: protective effects of microbial propionate upon the blood–brain barrier
Lesley Hoyles,Tom Snelling,Umm-Kulthum Umlai,Jeremy K. Nicholson,Simon R. Carding,Robert C. Glen,Simon McArthur +6 more
TL;DR: Interactions between circulating gut-derived microbial metabolites and the blood–brain barrier (BBB) also contribute to the gut–brain axis, representing a fourth facet of the gut-brain axis that warrants further attention.
Posted ContentDOI
Metabolic retroconversion of trimethylamine N-oxide and the gut microbiota
Lesley Hoyles,M.L. Jiménez-Pranteda,Julien Chilloux,Francois Brial,Antonis Myridakis,Thomas Aranias,Christophe Magnan,Glenn R. Gibson,Jeremy D. Sanderson,Jeremy K. Nicholson,Dominique Gauguier,Dominique Gauguier,Anne L. McCartney,Marc-Emmanuel Dumas +13 more
TL;DR: Reducing TMAO by the gut microbiota (predominantly Enterobacteriaceae) to TMA followed by host uptake of TMA into the bloodstream from the intestine and its conversion back to TTA by host hepatic enzymes is an example of metabolic retroconversion.
Posted ContentDOI
Cerebrovascular damage caused by the gut microbe-derived uraemic toxin p-cresol sulfate is prevented by blockade of the epidermal growth factor receptor
Sita Shah,Tobias B-A Knausenberger,Emily Charlotte Connell,Gwénaëlle Le Gall,Tom A. J. Hardy,David W Randall,Kieran McCafferty,Muhammad M. Yaqoob,Egle Solito,Michael Müller,Andrew V. Stachulski,Robert C. Glen,David Vauzour,Lesley Hoyles,Simon McArthur +14 more
TL;DR: In this article , the major uraemic toxin p-cresol sulfate (pCS) could affect the blood-brain barrier (BBB) integrity, and it was found that exposure of human hCMEC/D3 endothelial cells to pCS dose-dependently increased paracellular permeability and disrupted intercellular tight junctions, a permeabilising effect mirrored in mice.