L
Lesley Hoyles
Researcher at Nottingham Trent University
Publications - 120
Citations - 8449
Lesley Hoyles is an academic researcher from Nottingham Trent University. The author has contributed to research in topics: Microbiome & Medicine. The author has an hindex of 28, co-authored 102 publications receiving 6232 citations. Previous affiliations of Lesley Hoyles include University of Reading & University of Westminster.
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Journal ArticleDOI
Colonic bacterial metabolites and human health
TL;DR: The role of the gut microbiota in choline deficiency in non-alcoholic fatty liver disease (NAFLD) and insulin resistance is receiving increased attention, and the 'gut-liver axis' is an emerging area of study.
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Microbiome-host systems interactions: protective effects of propionate upon the blood-brain barrier.
Lesley Hoyles,Tom Snelling,Umm-Kulthum Umlai,Jeremy K. Nicholson,Simon R. Carding,Simon R. Carding,Robert C. Glen,Robert C. Glen,Simon McArthur +8 more
TL;DR: Interactions between circulating gut-derived microbial metabolites, and the blood–brain barrier (BBB) also contribute to the gut-brain axis, representing a fourth facet of the gut–brain axis that warrants further attention.
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Examination of faecal Bifidobacterium populations in breast- and formula-fed infants during the first 18 months of life
TL;DR: Overall, inter- and intra-individual differences were observed in the Bifidobacterium populations of infants between 1 and 18 months of age, although weaning was associated with increased diversity of the infant B ifidobacteria populations.
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Review article: the human intestinal virome in health and disease
TL;DR: High‐throughput, inexpensive, sensitive sequencing methods and metagenomics now make it possible to study the contribution dsDNA, ssDNA and RNA virus‐like particles make to the human virome, and in particular the intestinal virome.
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Metabolic retroconversion of trimethylamine N-oxide and the gut microbiota
Lesley Hoyles,M.L. Jiménez-Pranteda,Julien Chilloux,Francois Brial,Antonis Myridakis,Thomas Aranias,Christophe Magnan,Glenn R. Gibson,Jeremy D. Sanderson,Jeremy K. Nicholson,Dominique Gauguier,Dominique Gauguier,Anne L. McCartney,Marc-Emmanuel Dumas +13 more
TL;DR: Reduction of TMAO by the gut microbiota (predominantly Enterobacteriaceae) to TMA followed by host uptake of T MA into the bloodstream from the intestine and its conversion back to T MAO by host hepatic enzymes is an example of metabolic retroconversion.