L
Lesley Hoyles
Researcher at Nottingham Trent University
Publications - 120
Citations - 8449
Lesley Hoyles is an academic researcher from Nottingham Trent University. The author has contributed to research in topics: Microbiome & Medicine. The author has an hindex of 28, co-authored 102 publications receiving 6232 citations. Previous affiliations of Lesley Hoyles include University of Reading & University of Westminster.
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A network-based data-mining approach to investigate indole-related microbiota-host co-metabolism
Ana Luisa Neves,Andrea Rodriguez-Martinez,Rafael Ayala,Joram M. Posma,Abellona U M,Julien Chilloux,Jeremy K. Nicholson,Marc-Emmanuel Dumas,Lesley Hoyles +8 more
TL;DR: A computational strategy is proposed, comprising the integration of KEGG and BLAST, to identify prokaryote-specific metabolic reactions relevant for the production of indoles, as well as to predict new members of the human gut microbiota potentially involved in these reactions.
Posted ContentDOI
Microbiome Determinants and Physiological Effects of the Benzoate-Hippurate Microbial-Host Co-Metabolic Pathway
Francois Brial,Julien Chilloux,Trine Nielsen,Sara Vieira-Silva,Gwen Falony,Lesley Hoyles,Lesley Hoyles,Ana Luisa Neves,Andrea Rodriguez-Martinez,Ghiwa Ishac Mouawad,Nicolas Pons,Sofia K. Forslund,Aurélie M. Le Lay,Jeremy K. Nicholson,Torben Hansen,Karine Clément,Karine Clément,Peer Bork,S. Dusko Ehrlich,S. Dusko Ehrlich,Jeroen Raes,Oluf Pedersen,Dominique Gauguier,Dominique Gauguier,Dominique Gauguier,Marc-Emmanuel Dumas,Marc-Emmanuel Dumas +26 more
TL;DR: The translational study shows that the benzoate-hippurate pathway brings a range of metabolic improvements in the context of high-fat diets, highlighting the potential of hippurate as a mediator of metabolic health.
Posted ContentDOI
Extended genomic analyses of the broad-host-range phages vB_KmiM-2Di and vB_KmiM-4Dii reveal slopekviruses have highly conserved genomes
Thomas Smith-Zaitlik,Preetha Shibu,Anne L. McCartney,Geoffrey Foster,Lesley Hoyles,David Negus +5 more
TL;DR: Characterization of two lytic phages that were isolated from sewage water against two GES-5-positive Klebsiella michiganensis strains and found both showed broad lytic activity against KoC species suggest vB_KmiM-2Di and vB-4Dii represent attractive potential therapeutics.
Characterization of lytic bacteriophages of Klebsiella pneumoniae with capsular depolymerases
Thomas C. Brook,T Tijani,P Shibu,H Donaldson,Clokie,JS Sahota,A Markiv,Anne L. McCartney,Lesley Hoyles +8 more
TL;DR: In this paper, a host strain of Klebsiella pneumoniae, L4-FAA5 (K2:O1, ST380), was used as a host to isolate lytic bacteriophages from mixed-liquor sewage samples.