L
Liang Zhang
Researcher at City University of Hong Kong
Publications - 78
Citations - 3471
Liang Zhang is an academic researcher from City University of Hong Kong. The author has contributed to research in topics: Wnt signaling pathway & Transduction (genetics). The author has an hindex of 19, co-authored 70 publications receiving 2901 citations. Previous affiliations of Liang Zhang include University of Iowa & Mount Sinai Hospital.
Papers
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Journal ArticleDOI
Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration
Valbona Luga,Liang Zhang,Alicia Viloria-Petit,Abiodun A. Ogunjimi,Mohammad R. Inanlou,Elaine Chiu,Marguerite Buchanan,Abdel Nasser Hosein,Mark Basik,Jeffrey L. Wrana,Jeffrey L. Wrana +10 more
TL;DR: It is reported that fibroblast-secreted exosomes promote breast cancer cell (BCC) protrusive activity and motility via Wnt-planar cell polarity (PCP) signaling and it is demonstrated that exosome-stimulated BCC protrusions display mutually exclusive localization of the core PCP complexes.
Journal ArticleDOI
Regulation of Planar Cell Polarity by Smurf Ubiquitin Ligases
Masahiro Narimatsu,Rohit Bose,Rohit Bose,Melanie Pye,Liang Zhang,Bryan W. Miller,Peter Ching,Rui Sakuma,Valbona Luga,Valbona Luga,Luba Roncari,Liliana Attisano,Jeffrey L. Wrana,Jeffrey L. Wrana +13 more
TL;DR: It is shown that Smurfs engage in a noncanonical Wnt signaling pathway that targets the core PCP protein Prickle1 for ubiquitin-mediated degradation.
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Intracellular trafficking of adeno-associated viral vectors
TL;DR: The current understanding of events that control rAAV transduction following receptor binding and leading to nuclear uptake is summarized, finding these stages are broadly classified as intracellular trafficking and have been found to be a major rate-limiting step in AAV transduction for many cell types.
Journal ArticleDOI
Nox2 and Rac1 Regulate H2O2-Dependent Recruitment of TRAF6 to Endosomal Interleukin-1 Receptor Complexes
Qiang Li,Maged M. Harraz,Weihong Zhou,Liang Zhang,Wei Ding,Yulong Zhang,Tim Eggleston,Charles Yeaman,Botond Banfi,John F. Engelhardt +9 more
TL;DR: It is found that Nox2-derived ROS influence the formation of an active interleukin-1 (IL-1) receptor complex in the endosomal compartment by directing the H2O2-dependent binding of TRAF6 to the IL-1R1/MyD88 complex.
Journal Article
Human epithelial cancers secrete immunoglobulin g with unidentified specificity to promote growth and survival of tumor cells.
Xiaoyan Qiu,Xiaohui Zhu,Liang Zhang,Yuntao Mao,Jian Zhang,Peng Hao,Guohui Li,Peng Lv,Zhixin Li,Xin Sun,Lemeng Wu,Jie Zheng,Yu-qing Deng,Chunmei Hou,Peixian Tang,Shuren Zhang,Youhui Zhang +16 more
TL;DR: It is demonstrated that human cancers of epithelial origin, including carcinomas of breast, colon, liver, lung, established epithelial cancer lines, as well as some normal lung tissues, also produce IgG in both cytoplasmic and secreted forms, and a role of tumor-derived IgG as growth factor for epithelial cancers is supported.