B
Bryan W. Miller
Researcher at University of Toronto
Publications - 12
Citations - 1521
Bryan W. Miller is an academic researcher from University of Toronto. The author has contributed to research in topics: Wnt signaling pathway & Phosphorylation. The author has an hindex of 10, co-authored 12 publications receiving 1373 citations. Previous affiliations of Bryan W. Miller include University of Leicester & University of Glasgow.
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Journal ArticleDOI
The Hippo Pathway Regulates Wnt/β-Catenin Signaling
Xaralabos Varelas,Bryan W. Miller,Richelle Sopko,Richelle Sopko,Siyuan Song,Alex Gregorieff,Frederic A. Fellouse,Rui Sakuma,Tony Pawson,Tony Pawson,Walter Hunziker,Helen McNeill,Helen McNeill,Jeffrey L. Wrana,Jeffrey L. Wrana,Liliana Attisano +15 more
TL;DR: It is shown that the Hippo pathway restricts Wnt/beta-Catenin signaling by promoting an interaction between TAZ and DVL in the cytoplasm, and this work highlights the role of the hippo pathway in coordinating morphogenetic signaling with growth control.
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Regulation of Planar Cell Polarity by Smurf Ubiquitin Ligases
Masahiro Narimatsu,Rohit Bose,Rohit Bose,Melanie Pye,Liang Zhang,Bryan W. Miller,Peter Ching,Rui Sakuma,Valbona Luga,Valbona Luga,Luba Roncari,Liliana Attisano,Jeffrey L. Wrana,Jeffrey L. Wrana +13 more
TL;DR: It is shown that Smurfs engage in a noncanonical Wnt signaling pathway that targets the core PCP protein Prickle1 for ubiquitin-mediated degradation.
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Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy.
Bryan W. Miller,Jennifer P. Morton,Mark Pinese,Grazia Saturno,Nigel B. Jamieson,Ewan J. McGhee,Paul Timpson,Joshua D.G. Leach,Lynn McGarry,Emma Shanks,Peter Bailey,David K. Chang,Karin A. Oien,Saadia A. Karim,Amy Au,Colin W. Steele,C.R. Carter,Colin J. McKay,Kurt I. Anderson,Thomas R. Jeffry Evans,Richard Marais,Caroline J. Springer,Andrew V. Biankin,Janine T. Erler,Owen J. Sansom +24 more
TL;DR: It is found that LOX expression is upregulated in metastatic tumors from Pdx1‐Cre KrasG12D/+ Trp53R172H/+ (KPC) mice and that inhibition of LOX in these mice suppressed metastasis, and LOX inhibition is able to reverse many of the features that make PDAC inherently refractory to conventional therapies.
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Mutant p53–associated myosin-X upregulation promotes breast cancer invasion and metastasis
Antti Arjonen,Riina Kaukonen,Elina Mattila,Pegah Rouhi,Gunilla Högnäs,Harri Sihto,Bryan W. Miller,Jennifer P. Morton,Elmar Bucher,Pekka Taimen,Pekka Taimen,Reetta Virtakoivu,Yihai Cao,Yihai Cao,Owen J. Sansom,Heikki Joensuu,Johanna Ivaska +16 more
TL;DR: Data indicate that Myo10 upregulation in mutant p53-driven cancers is necessary for invasion and that plasma-membrane protrusions, such as filopodia, may serve as specialized metastatic engines.
Journal ArticleDOI
Wnt inhibitor screen reveals iron dependence of β-catenin signaling in cancers.
Siyuan Song,Tania Christova,Stephen Perusini,Solmaz Alizadeh,Ren-Yue Bao,Bryan W. Miller,Rose Hurren,Yulia Jitkova,Marcela Gronda,Methvin Isaac,Babu Joseph,Ratheesh Subramaniam,Ahmed Aman,Anh Chau,Donna E. Hogge,Scott Weir,James Kasper,Aaron D. Schimmer,Rima Al-awar,Jeffery L. Wrana,Liliana Attisano +20 more
TL;DR: A series of acyl hydrazones that act downstream of the β-catenin destruction complex to inhibit both Wnt-induced and cancer-associated constitutive Wnt signaling via destabilization of β-Catenin are identified.