L
Lili Wu
Researcher at Chinese Academy of Sciences
Publications - 26
Citations - 3143
Lili Wu is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 8, co-authored 12 publications receiving 1786 citations.
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Journal ArticleDOI
Structural and Functional Basis of SARS-CoV-2 Entry by Using Human ACE2.
Qihui Wang,Yanfang Zhang,Lili Wu,Sheng Niu,Sheng Niu,Chunli Song,Chunli Song,Zengyuan Zhang,Guangwen Lu,Chengpeng Qiao,Yu Hu,Yu Hu,Kwok-Yung Yuen,Qisheng Wang,Huan Zhou,Jinghua Yan,Jianxun Qi +16 more
TL;DR: The crystal structure of the C-terminal domain of SARS-CoV-2 (SARS- coV- 2-CTD) spike (S) protein in complex with human ACE2 (hACE2) is presented, which reveals a hACE2-binding mode similar overall to that observed for SARS -CoV.
Journal ArticleDOI
Safety and immunogenicity of a recombinant tandem-repeat dimeric RBD-based protein subunit vaccine (ZF2001) against COVID-19 in adults: two randomised, double-blind, placebo-controlled, phase 1 and 2 trials.
Shilong Yang,Yan Li,Lianpan Dai,Jianfeng Wang,Peng He,Changgui Li,Xin Fang,Chenfei Wang,Xiang Zhao,Enqi Huang,Changwei Wu,Zaixin Zhong,F.S. Wang,Xiaomin Duan,Siyu Tian,Lili Wu,Yan Liu,Yi Luo,Zhihai Chen,Fangjun Li,Junhua Li,Xian Yu,Hong Ren,Lihong Liu,Shufang Meng,Jinghua Yan,Zhongyu Hu,Lidong Gao,George F. Gao +28 more
TL;DR: ZF2001 as discussed by the authors is a protein subunit vaccine against COVID-19 using a dimeric form of the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein as the antigen.
Journal ArticleDOI
Broad host range of SARS-CoV-2 and the molecular basis for SARS-CoV-2 binding to cat ACE2
Lili Wu,Qian Chen,Qian Chen,Kefang Liu,Kefang Liu,Jia Wang,Pengcheng Han,Yanfang Zhang,Yu Hu,Yu Hu,Yumin Meng,Xiaoqian Pan,Chengpeng Qiao,Siyu Tian,Pei Du,Hao Song,Weifeng Shi,Jianxun Qi,Hong-Wei Wang,Jinghua Yan,George F. Gao,Qihui Wang,Qihui Wang +22 more
TL;DR: Cutting light on pursuing the intermediate host of SARS-CoV-2 is shed and the necessity of monitoring susceptible hosts to prevent further outbreaks is highlighted.
Journal ArticleDOI
Binding and molecular basis of the bat coronavirus RaTG13 virus to ACE2 in humans and other species.
Kefang Liu,Xiaoqian Pan,Linjie Li,Feng Yu,Anqi Zheng,Pei Du,Pengcheng Han,Yumin Meng,Yanfang Zhang,Lili Wu,Qian Chen,Chunli Song,Yunfei Jia,Sheng Niu,Sheng Niu,Dan Lu,Chengpeng Qiao,Zhihai Chen,Dongli Ma,Xiaopeng Ma,Shuguang Tan,Xin Zhao,Jianxun Qi,George F. Gao,Qihui Wang +24 more
TL;DR: In this paper, the complex structure of the RaTG13 receptor binding domain (RBD) with human ACE2 (hACE2) was obtained and evaluated binding of RBD to 24 additional ACE2 orthologs.
Journal ArticleDOI
Cross-species recognition of SARS-CoV-2 to bat ACE2.
Kefang Liu,Shuguang Tan,Sheng Niu,Sheng Niu,Jia Wang,Lili Wu,Huan Sun,Yanfang Zhang,Xiaoqian Pan,Xiao Qu,Pei Du,Yumin Meng,Yunfei Jia,Yunfei Jia,Qian Chen,Qian Chen,Chu-Xia Deng,Jinghua Yan,Hong-Wei Wang,Qihui Wang,Jianxun Qi,George F. Gao +21 more
TL;DR: The SARS-CoV-2 spike protein receptor binding domain (RBD) could bind to bACE2 from Rhinolophus macrotis (bACE2-Rm) with substantially lower affinity compared with that to the human ACE2 (hACE2) for virus infection.