Lingbo Wang

TL;DR: It is determined that Zscan4, in combination with the Yamanaka factors, not only remarkably reduced the DDR but also markedly promoted the efficiency of iPS cell generation, providing the first demonstration that maintaining genomic stability during reprogramming promotes the generation of high quality iPS cells.

TL;DR: It is shown that mouse embryonic stem cells depleted of Tet1 and/or Tet2 by RNAi exhibit short telomeres and chromosomal instability, concomitant with reduced telomere recombination, and Tet1/2/3 triple knockout in ESCs consistently upregulates Zscan4, which may counteractTelomere shortening.

TL;DR: In this article, the authors compared the creep performance of as-forged and as-cast Inconel 718 via small-punch creep test technique and found that the SLM-fabricated samples have a time to rupture approximately equal to that of the asforged samples but much less than the as cast sample due to the difference in the microstructures introduced by these manufacture processes.

TL;DR: A method for rapidly inducing CRISPR-Cas9-mediated mutations in one blastomere of two-cell stage embryos is established, termed 2-cell embryo-CRISPR -Cas9 injection (2CC), to study the in vivo function of essential (or unknown) genes in founder chimeric mice.

TL;DR: In this article, the effects of the surface roughness and the build thickness on fatigue properties of selective laser melted Inconel 718 were investigated at 650°C and the result indicated that fatigue strength was enhanced by ~50% after surface machining and polishing.