L
Lorena Pantano
Researcher at Harvard University
Publications - 49
Citations - 4719
Lorena Pantano is an academic researcher from Harvard University. The author has contributed to research in topics: Small RNA & microRNA. The author has an hindex of 21, co-authored 46 publications receiving 3620 citations. Previous affiliations of Lorena Pantano include Pompeu Fabra University & Catalan Institution for Research and Advanced Studies.
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Journal ArticleDOI
Screening for YAP Inhibitors Identifies Statins as Modulators of Fibrosis.
Daniela M. Santos,Lorena Pantano,Gina Pronzati,Paula Grasberger,Clemens K. Probst,Katharine E. Black,Jillian J Spinney,Lida P. Hariri,Royale Nichols,Yufei Lin,Michael Bieler,Peter Seither,Paul Nicklin,David Wyatt,Andrew M. Tager,Benjamin D. Medoff +15 more
TL;DR: A high-throughput small molecule screen for YAP inhibitors in primary human lung fibroblasts shows that the mevalonate pathway regulates YAP activation, and that simvastatin treatment reduces fibrosis markers in activated HLF and in the bleomycin mouse model of pulmonary fibrosis.
Journal ArticleDOI
Unification of miRNA and isomiR research: the mirGFF3 format and the mirtop API.
Thomas Desvignes,Phillipe Loher,Karen Eilbeck,Jeffery Ma,Gianvito Urgese,Bastian Fromm,Jason Sydes,Ernesto Aparicio-Puerta,Victor Barrera,Roderic Espín,Florian Thibord,Florian Thibord,Xavier Bofill-De Ros,Eric Londin,Aristeidis G. Telonis,Elisa Ficarra,Marc R. Friedländer,John H. Postlethwait,Isidore Rigoutsos,Michael Hackenberg,Ioannis S. Vlachos,Marc K. Halushka,Lorena Pantano +22 more
TL;DR: A community-based project, miRTOP (miRNA Transcriptomic Open Project) working towards the optimization of miRNA analyses, which creates a new standard format, mirGFF3, for the output of mi RNA/isomiR detection and quantification results from small RNA-seq data.
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Specific small-RNA signatures in the amygdala at premotor and motor stages of Parkinson’s disease revealed by deep sequencing analysis
Lorena Pantano,Marc R. Friedländer,Geòrgia Escaramís,Esther Lizano,Joan Pallarès-Albanell,Isidre Ferrer,Isidre Ferrer,Xavier Estivill,Eulàlia Martí +8 more
TL;DR: A pipeline to non-redundantly quantify all types of sRNAs, and extract patterns of expression in biologically defined groups is developed, which revealed sRNA alterations at premotor stages of PD, which might reflect initial pathogenic perturbations.
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Empirical comparison of reduced representation bisulfite sequencing and Infinium BeadChip reproducibility and coverage of DNA methylation in humans.
Juan Carmona,William P. Accomando,William P. Accomando,Alexandra M. Binder,Alexandra M. Binder,John N. Hutchinson,Lorena Pantano,Benedetta Izzi,Allan C. Just,Xihong Lin,Joel Schwartz,Pantel S. Vokonas,Sami S. Amr,Sami S. Amr,Andrea A. Baccarelli,Karin B. Michels,Karin B. Michels +16 more
TL;DR: The former did a better job at reading methylation in protein-coding and mitochondrial-related genes, while the latter required less input DNA and covered more methylation sites across the genome.
Journal ArticleDOI
Multi omics analysis of fibrotic kidneys in two mouse models
Mira Pavkovic,Mira Pavkovic,Lorena Pantano,Cory V. Gerlach,Cory V. Gerlach,Sergine Brutus,Sarah A. Boswell,Robert A. Everley,Jagesh V. Shah,Jagesh V. Shah,Shannan J. Ho Sui,Vishal S. Vaidya,Vishal S. Vaidya +12 more
TL;DR: In this article, the authors presented a comprehensive and combined multi-omics dataset (proteomics, mRNA and small RNA transcriptomics) of fibrotic kidneys that is searchable through a user-friendly web application: http://hbcreports.med.harvard.edu/fmm/