L
Lorena Pantano
Researcher at Harvard University
Publications - 49
Citations - 4719
Lorena Pantano is an academic researcher from Harvard University. The author has contributed to research in topics: Small RNA & microRNA. The author has an hindex of 21, co-authored 46 publications receiving 3620 citations. Previous affiliations of Lorena Pantano include Pompeu Fabra University & Catalan Institution for Research and Advanced Studies.
Papers
More filters
Journal ArticleDOI
The small RNA content of human sperm reveals pseudogene-derived piRNAs complementary to protein-coding genes
Lorena Pantano,Meritxell Jodar,Mads Bak,Josep Lluís Ballescà,Niels Tommerup,Niels Tommerup,Rafael Oliva,Tanya Vavouri +7 more
TL;DR: This study sequenced and characterized the small RNA content of sperm samples from two human fertile individuals and found that human sperm cells contain piRNAs processed from pseudogenes, suggesting that some of the pseudogene-derived human pi RNAs may regulate expression of their parent gene in the male germline.
Journal ArticleDOI
Targeting acid ceramidase inhibits YAP/TAZ signaling to reduce fibrosis in mice.
Sarah Alsamman,Stephanie A. Christenson,Amy Yu,Nadia M. E. Ayad,Nadia M. E. Ayad,Meghan S. Mooring,Joe M. Segal,Jimmy Kuang-Hsien Hu,Johanna R. Schaub,Steve S. Ho,Vikram R. Rao,Megan M. Marlow,Scott M. Turner,Mai Sedki,Lorena Pantano,Sarani Ghoshal,Diego dos Santos Ferreira,Hsiao-Yen Ma,Caroline C. Duwaerts,Regina Español-Suñer,Lan Wei,Benjamin Newcomb,Izolda Mileva,Daniel Canals,Yusuf A. Hannun,Raymond T. Chung,Aras N. Mattis,Bryan C. Fuchs,Andrew M. Tager,Dean Yimlamai,Valerie M. Weaver,Alan C. Mullen,Dean Sheppard,Jennifer Y. Chen +33 more
TL;DR: It is demonstrated that targeting aCDase inhibits YAP/TAZ activity by potentiating its phosphorylation-mediated proteasomal degradation via the ubiquitin ligase adaptor protein β-TrCP.
Journal ArticleDOI
InvFEST, a database integrating information of polymorphic inversions in the human genome
Alexander Martínez-Fundichely,Sònia Casillas,Raquel Egea,Miquel Ràmia,Antonio Barbadilla,Lorena Pantano,Marta Sabariego Puig,Mario Cáceres +7 more
TL;DR: InvFEST aims to represent the most reliable set of human inversions and become a central repository to share information, guide future studies and contribute to the analysis of the functional and evolutionary impact of inversions on the human genome.
Journal ArticleDOI
Circulating miRNAs, isomiRs and small RNA clusters in human plasma and breast milk.
Mercedes Rubio,Mariona Bustamante,Carles Hernandez-Ferrer,Dietmar Fernández-Orth,Lorena Pantano,Yaris Sarria,Maria Riera Piqué-Borràs,Kilian Vellvé,Silvia Agramunt,Ramon Carreras,Xavier Estivill,Juan R. González,Alfredo Mayor,Alfredo Mayor +13 more
TL;DR: In summary, plasma and milk showed a different small RNA profile, confirming the presence of non-miRNA species in plasma, and describing them for the first time in milk.
Journal ArticleDOI
A non-biased framework for the annotation and classification of the non-miRNA small RNA transcriptome
TL;DR: SeqCluster is presented, an extension of the currently available SeqBuster tool to identify and analyze at different levels the sRNAs not annotated or predicted as miRNAs, which deals with sequences mapping onto multiple locations and permits a highly versatile and user-friendly interaction with the data in order to easily classify sRNA sequences with a putative functional importance.