L
Lorena Pantano
Researcher at Harvard University
Publications - 49
Citations - 4719
Lorena Pantano is an academic researcher from Harvard University. The author has contributed to research in topics: Small RNA & microRNA. The author has an hindex of 21, co-authored 46 publications receiving 3620 citations. Previous affiliations of Lorena Pantano include Pompeu Fabra University & Catalan Institution for Research and Advanced Studies.
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Journal ArticleDOI
Molecular, phenotypic, and sample-associated data to describe pluripotent stem cell lines and derivatives
Kenneth Daily,Shannan J. Ho Sui,Lynn M. Schriml,Phillip J. Dexheimer,Nathan Salomonis,Robin Schroll,Stacy Bush,Mehdi Keddache,Christopher N. Mayhew,Samad Lotia,Thanneer M. Perumal,Kristen K. Dang,Lorena Pantano,Alexander R. Pico,Elke Grassman,Diana Nordling,Winston Hide,Winston Hide,Antonis K. Hatzopoulos,Punam Malik,Jose A. Cancelas,Carolyn Lutzko,Bruce J. Aronow,Larsson Omberg +23 more
TL;DR: The goal is to provide data that can improve the ability to robustly and reproducibly use human pluripotent stem cells to understand development and disease.
Journal ArticleDOI
Maintenance of macrophage transcriptional programs and intestinal homeostasis by epigenetic reader SP140.
Stuti Mehta,D. Alexander Cronkite,Megha Basavappa,Tahnee L. Saunders,Fatemeh Adiliaghdam,Hajera Amatullah,Sara A. Morrison,Jose D. Pagan,Robert M. Anthony,Pierre Tonnerre,Georg M. Lauer,James Lee,Sreehaas Digumarthi,Lorena Pantano,Shannan J. Ho Sui,Fei Ji,Ruslan I. Sadreyev,Chan Zhou,Alan C. Mullen,Vinod Kumar,Yang Li,Cisca Wijmenga,Ramnik J. Xavier,Terry K. Means,Kate L. Jeffrey +24 more
TL;DR: It is shown that SP140 is critical for transcriptional programs that uphold the macrophage state, and a loss of SP140 due to genetic variation contributes to a molecularly defined subset of CD characterized by ineffective innate immunity, normally critical for intestinal homeostasis.
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Identification of copy number variants defining genomic differences among major human groups.
Lluís Armengol,Sergi Villatoro,Juan R. González,Lorena Pantano,Manel García-Aragonés,Raquel Rabionet,Mario Cáceres,Xavier Estivill +7 more
TL;DR: This work investigates the genome-wide profile of structural variation on pooled samples from the three populations studied in the HapMap project by comparative genome hybridization (CGH) in different array platforms and identifies 33 genomic loci that show significant copy number differences from one population to the other.
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Microarray and deep sequencing cross-platform analysis of the mirRNome and isomiR variation in response to epidermal growth factor
Franc Llorens,Manuela Hummel,Lorena Pantano,Xavier Pastor,Ana Vivancos,Ester Castillo,Heidi Mattlin,Anna Ferrer,Matthew Ingham,Marc Noguera,Robert Kofler,Juliane C. Dohm,Juliane C. Dohm,Raquel Pluvinet,Mònica Bayés,Heinz Himmelbauer,José Antonio del Río,Eulàlia Martí,Lauro Sumoy +18 more
TL;DR: It is proposed that the use of global genomic miRNA cross-validation derived from high throughput technologies can be used to generate more reliable datasets inferring more robust networks of co-regulated predicted miRNA target genes.
Journal ArticleDOI
Evolutionary and functional impact of common polymorphic inversions in the human genome
Carla Giner-Delgado,Sergi Villatoro,Jon Lerga-Jaso,Magdalena Gayà-Vidal,Magdalena Gayà-Vidal,Meritxell Oliva,David Castellano,Lorena Pantano,Bárbara Domingues Bitarello,David Izquierdo,Isaac Noguera,Iñigo Olalde,Alejandra Delprat,Antoine Blancher,Carles Lalueza-Fox,Tõnu Esko,Paul F. O'Reilly,Aida M. Andrés,Aida M. Andrés,Luca Ferretti,Marta Sabariego Puig,Mario Cáceres +21 more
TL;DR: The results indicate that the genome is more dynamic than previously thought and that human inversions have important functional and evolutionary consequences, making possible to determine for the first time their contribution to complex traits.