Lorenzo Colarossi

TL;DR: In this article, the authors show that visceral adipose derived factors promote vasculogenesis and metastatic dissemination by activation of STAT3, which inhibits miR-200a and enhances ZEB2 expression, effectively reprogramming colorectal cancer cells into a highly metastatic phenotype.

TL;DR: In this paper, the authors reported that exposure to a neo-synthetic bis(indolyl)thiazole alkaloid analog, nortopsentin 234 (NORA234), leads to an initial reduction of proliferative and clonogenic potential of CRC sphere cells, followed by an adaptive response selecting the CR-CSphC-resistant compartment.

TL;DR: In this article, a review summarizes the numerous research advances regarding the development of calixarene nanoparticles capable of encapsulating various anticancer drugs in a controlled way, and shows that the use of these drugs as carriers of cancer drugs could reduce their side effects and increase their affinity towards the target.

TL;DR: This work has investigated class IIa HDAC expression and inhibition in gastric cancer cells and found no significant differences between the three classes of HDACs studied.

TL;DR: In this paper, a combinatorial approach was proposed to perturb the interaction network between CSCs and the different component of TME, which strengthened CSC refractoriness to standard and targeted therapies by enhancing survival signaling pathways, DNA repair machinery, expression of drug efflux transporters and anti-apoptotic proteins.