L
Lorna C. Webster
Researcher at University of Edinburgh
Publications - 5
Citations - 1668
Lorna C. Webster is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Regulatory site & Nucleotide. The author has an hindex of 5, co-authored 5 publications receiving 1602 citations.
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Journal ArticleDOI
Enhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 protein
Martine Migaud,Paul Charlesworth,M. Dempster,Lorna C. Webster,Ayako M. Watabe,Michael Makhinson,Yong He,M. Ramsay,Richard G. M. Morris,John H. Morrison,Thomas J. O'Dell,Seth G. N. Grant +11 more
TL;DR: In mutant mice lacking PSD-95, the frequency function of NMDA-dependent LTP and LTD is shifted to produce strikingly enhanced LTP at different frequencies of synaptic stimulation, which is accompanied by severely impaired spatial learning.
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Importance of the Intracellular Domain of NR2 Subunits for NMDA Receptor Function In Vivo
Rolf Sprengel,Bettina Suchanek,Carla Amico,Rossella Brusa,Nail Burnashev,Andrei Rozov,OØivind Hvalby,Vidar Jensen,Ole Paulsen,Per Andersen,Jeansok J. Kim,Richard F. Thompson,William Sun,Lorna C. Webster,Seth G. N. Grant,Jens Eilers,Arthur Konnerth,Jianying Li,James O. McNamara,Peter H. Seeburg +19 more
TL;DR: It is shown that gene-targeted mice expressing NMDA receptors without the large intracellular C-terminal domain of any one of three NR2 subunits phenotypically resemble mice made deficient in that particular subunit.
Journal ArticleDOI
Interaction of Organotins with a Vacuolar-Type H+-ATPase
David K. Apps,Lorna C. Webster +1 more
TL;DR: There is a specific interaction between organotin compounds and V-ATPase subunit A, in the catalytic sector of the enzyme, which is concluded to be related to fluorescence enhancement in the 3-hydroxyflavone complex.
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Analysis of Nucleotide Binding by a Vacuolar Proton‐Translocating Adenosine Triphosphatase
Lorna C. Webster,David K. Apps +1 more
TL;DR: The vacuolar-type proton-translocatine adenosine triphosphatase from bovine adrenal secretory granules was purified and reconstituted into proteoliposomes and the binding of nucleotides to the enzyme was studied, confirming the existence of a single regulatory site for MgADP.
Journal ArticleDOI
Allosteric regulation of proton translocation by a vacuolar adenosinetriphosphatase.
TL;DR: The kinetics of nucleoside-triphosphate-dependent proton translocation by a vacuolar-type adenosine-Triphosphatase have been studied, using the enzyme from bovine chromaffin-granule membranes, purified and reconstituted into proteoliposomes.