Louise A. Swainson

TL;DR: Comparing acute pathogenic SIV infection in pigtailed macaques to non-pathogenic infection in African green monkeys indicates that loss of the Th17 to Treg balance is related to SIV disease progression.

TL;DR: The estimated size of the residual tissue burden of 108 vDNA+ cells potentially containing replication-competent proviruses, along with evidence of continuing virus production in LT despite ART, indicated two important sources for rebound following treatment interruption.

TL;DR: It is proposed that Lactobacillus species inhibit mammalian IDO1 and thus may help to preserve Th17 cells during pathogenic SIV infection, providing support for Lactobaecillus species as modulators of mucosal immune homeostasis.

TL;DR: It is shown that FcRL3 is expressed on a population of thymically derived Treg that exhibits a memory phenotype and high levels of programmed cell death-1, and data suggest that F cRL3 expression is associated with Treg dysfunction that may, in turn, contribute to the loss of self-tolerance and the development of autoimmunity.

TL;DR: Findings indicate that FcRL3 expression, which is strongly associated with the presence of the FCRL3 -169C allele, may serve as a biomarker for RA disease activity.