S
Susan V. Lynch
Researcher at University of California, San Francisco
Publications - 223
Citations - 23454
Susan V. Lynch is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Microbiome & Medicine. The author has an hindex of 62, co-authored 198 publications receiving 18399 citations. Previous affiliations of Susan V. Lynch include University of California & University of California, Berkeley.
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Journal ArticleDOI
Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria
Ivaylo I. Ivanov,Koji Atarashi,Nicolas Manel,Eoin L. Brodie,Tatsuichiro Shima,Ulas Karaoz,Dongguang Wei,Katherine C. Goldfarb,Clark A. Santee,Susan V. Lynch,Takeshi Tanoue,Akemi Imaoka,Kikuji Itoh,Kiyoshi Takeda,Yoshinori Umesaki,Kenya Honda,Dan R. Littman +16 more
TL;DR: The authors showed that colonisation of mice with a segmented filamentous bacterium (SFB) is sufficient to induce the appearance of CD4+ T helper cells that produce IL-17 and IL-22 (Th17 cells) in the lamina propria.
Journal ArticleDOI
The Human Intestinal Microbiome in Health and Disease
Susan V. Lynch,Oluf Pedersen +1 more
TL;DR: The large majority of studies on the role of the microbiome in the pathogenesis of disease are correlative and preclinical; several have influenced clinical practice.
Journal ArticleDOI
Current understanding of the human microbiome.
Jack A. Gilbert,Jack A. Gilbert,Jack A. Gilbert,Martin J. Blaser,J. Gregory Caporaso,Janet K. Jansson,Susan V. Lynch,Rob Knight +7 more
TL;DR: This review focuses on studies in humans to describe challenges and propose strategies that leverage existing knowledge to move rapidly from correlation to causation and ultimately to translation into therapies.
Journal ArticleDOI
Neonatal gut microbiota associates with childhood multisensitized atopy and T cell differentiation
Kei E. Fujimura,Alexandra R. Sitarik,Suzanne Havstad,Din L. Lin,Sophia R. Levan,Douglas Fadrosh,Ariane R. Panzer,Brandon LaMere,Elze Rackaityte,Nicholas W. Lukacs,Ganesa Wegienka,Homer A. Boushey,Dennis R. Ownby,Edward M. Zoratti,Albert M. Levin,Christine Cole Johnson,Susan V. Lynch +16 more
TL;DR: It is suggested that neonatal gut microbiome dysbiosis might promote CD4+ T cell dysfunction associated with childhood atopy, and the effect of NGM3 fecal water on relativeCD4+CD25+FOXP3+ cell abundance.
Journal ArticleDOI
Comparison of the Respiratory Microbiome in Healthy Nonsmokers and Smokers
Alison Morris,James M. Beck,Patrick D. Schloss,Thomas B. Campbell,Kristina Crothers,Jeffrey L. Curtis,Sonia C. Flores,Andrew P. Fontenot,Elodie Ghedin,Laurence Huang,Kathleen A. Jablonski,Eric C. Kleerup,Susan V. Lynch,Erica Sodergren,Homer L. Twigg,Vincent B. Young,Christine M. Bassis,Arvind Venkataraman,Thomas M. Schmidt,George M. Weinstock +19 more
TL;DR: This study is the largest to examine composition of the lower respiratory tract microbiome in healthy individuals and the first to use the neutral model to compare the lung to the mouth, demonstrating that the lung microbiome does not derive entirely from the mouth.