D
David Favre
Researcher at University of California, San Francisco
Publications - 17
Citations - 2277
David Favre is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Simian immunodeficiency virus & Immune system. The author has an hindex of 15, co-authored 16 publications receiving 2152 citations. Previous affiliations of David Favre include French Institute of Health and Medical Research.
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Journal ArticleDOI
Tryptophan catabolism by indoleamine 2,3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV disease.
David Favre,Jeff E. Mold,Peter W. Hunt,Bittoo Kanwar,P'ng Loke,Lillian Seu,Jason D. Barbour,Margaret M. Lowe,Anura Jayawardene,Francesca T. Aweeka,Yong Huang,Daniel C. Douek,Jason M. Brenchley,Jeffrey N. Martin,Frederick Hecht,Steven G. Deeks,Joseph M. McCune +16 more
TL;DR: Patients with AIDS have fewer immune cells to defend against microbial invasion through the gut, a critical loss that may be caused by a tryptophan metabolite produced by other immune cells, and IDO1 inhibitors are being tested for their efficacy in interfering with this dangerous depletion of defenses.
Journal ArticleDOI
Critical loss of the balance between Th17 and T regulatory cell populations in pathogenic SIV infection.
David Favre,Sharon Lederer,Bittoo Kanwar,Zhong-Min Ma,Sean Proll,Zeljka Kasakow,Jeff E. Mold,Louise A. Swainson,Jason D. Barbour,Carole R. Baskin,Robert E. Palermo,Ivona Pandrea,Christopher J. Miller,Michael G. Katze,Joseph M. McCune +14 more
TL;DR: Comparing acute pathogenic SIV infection in pigtailed macaques to non-pathogenic infection in African green monkeys indicates that loss of the Th17 to Treg balance is related to SIV disease progression.
Journal ArticleDOI
Factors influencing recombinant adeno-associated virus production.
Anna Salvetti,Soizic Orève,Gilliane Chadeuf,David Favre,Yan Cherel,Patrick Champion-Arnaud,Jacques David-Ameline,Philippe Moullier +7 more
TL;DR: A general method to titrate rAAV, independently of the transgene and its expression, and to measure the level of contamination with adenovirus and rep-positive AAV is described.
Journal ArticleDOI
Phenotypic, Functional, and Kinetic Parameters Associated with Apparent T-Cell Control of Human Immunodeficiency Virus Replication in Individuals with and without Antiretroviral Treatment
Brinda Emu,Elizabeth Sinclair,David Favre,Walter J. Moretto,Priscilla Y. Hsue,Rebecca Hoh,Jeffrey N. Martin,Douglas F. Nixon,Joseph M. McCune,Steven G. Deeks +9 more
TL;DR: Control of HIV replication is associated with high levels of HIV-specific IL-2+ and IFN-γ+ CD4+ T cells and low levels of T-cell activation, suggesting that functional immunity can be reconstituted with partially suppressive highly active antiretroviral therapy.
Journal ArticleDOI
Th17 and regulatory T cells: implications for AIDS pathogenesis.
TL;DR: It remains unclear, however, whether Th17 cells are preferentially infected or if, instead, their loss is induced by bystander effects of lentiviral infection, for example, the induction of indoleamine 2,3-dioxygenase.