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Bo Zhong
Researcher at Wuhan University
Publications - Â 79
Citations - Â 6428
Bo Zhong is an academic researcher from Wuhan University. The author has contributed to research in topics: Signal transduction & IRF3. The author has an hindex of 33, co-authored 73 publications receiving 4963 citations. Previous affiliations of Bo Zhong include University of Texas MD Anderson Cancer Center.
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Journal ArticleDOI
The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation
Bo Zhong,Yan Yang,Shu Li,Yan-Yi Wang,Ying Li,Feici Diao,Cao-Qi Lei,Xiao He,Lu Zhang,Po Tien,Hong-Bing Shu +10 more
TL;DR: The results suggest that MITA is a critical mediator of virus-triggered IRF3 activation and IFN expression and further demonstrate the importance of certain mitochondrial proteins in innate antiviral immunity.
Journal ArticleDOI
The Ubiquitin Ligase RNF5 Regulates Antiviral Responses by Mediating Degradation of the Adaptor Protein MITA
Bo Zhong,Lu Zhang,Cao-Qi Lei,Ying Li,Ai-Ping Mao,Yan Yang,Yan-Yi Wang,Xiao-Lian Zhang,Hong-Bing Shu +8 more
TL;DR: It is shown that the E3 ubiquitin ligase RNF5 interacted with MITA in a viral-infection-dependent manner and found that virus-induced ubiquitination and degradation of MITA by R NF5 occurred at the mitochondria.
Journal ArticleDOI
Transcription factor achaete-scute homologue 2 initiates follicular T-helper-cell development
Xindong Liu,Xindong Liu,Xin Chen,Bo Zhong,Bo Zhong,Aibo Wang,Aibo Wang,Xiaohu Wang,Xiaohu Wang,Fuliang Chu,Roza Nurieva,Xiaowei Yan,Ping Chen,Laurens G. van der Flier,Hiroko Nakatsukasa,Sattva S. Neelapu,Wanjun Chen,Hans Clevers,Qiang Tian,Hai Qi,Lai Wei,Chen Dong,Chen Dong +22 more
TL;DR: Genome-wide analysis indicates that Ascl2 directly regulates TFH-related genes whereas it inhibits expression of T-helper cell 1 (TH1) and TH17 signature genes.
Journal ArticleDOI
Genome-wide analysis identifies NR4A1 as a key mediator of T cell dysfunction.
Xindong Liu,Yun Wang,Huiping Lu,Jing Li,Xiaowei Yan,Minglu Xiao,Jing Hao,Andrei Alekseev,Hiep Khong,Tenghui Chen,Rui Huang,Jin Wu,Qiwen Zhao,Qi Wu,Sen-Lin Xu,Xiaohu Wang,Wei Jin,Shi-cang Yu,Yan Wang,Lai Wei,Aibo Wang,Bo Zhong,Ling Ni,Xiaolong Liu,Roza Nurieva,Lilin Ye,Qiang Tian,Xiu-Wu Bian,Chen Dong +28 more
TL;DR: Tolerant T cells display characteristic patterns of gene expression and epigenetics that are distinct from other types of T cells and are orchestrated by the transcription factor NR4A1, a potential target for tumour immunotherapy.
Journal ArticleDOI
Bcl6 expression specifies the T follicular helper cell program in vivo
Xindong Liu,Xiaowei Yan,Bo Zhong,Roza Nurieva,Aibo Wang,Xiaohu Wang,Natalia Martin-Orozco,Yi-Hong Wang,Seon Hee Chang,Enric Esplugues,Richard A. Flavell,Qiang Tian,Chen Dong +12 more
TL;DR: A novel Bcl6 reporter mouse is used to dissect the developmental requirements, plasticity, and genetic profile of Tfh cells.