L
Lucía Otero
Researcher at University of the Republic
Publications - 49
Citations - 1701
Lucía Otero is an academic researcher from University of the Republic. The author has contributed to research in topics: Trypanosoma cruzi & Ruthenium. The author has an hindex of 24, co-authored 46 publications receiving 1542 citations. Previous affiliations of Lucía Otero include Pasteur Institute.
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Journal ArticleDOI
Novel antitrypanosomal agents based on palladium nitrofurylthiosemicarbazone complexes: DNA and redox metabolism as potential therapeutic targets.
Lucía Otero,Marisol Vieites,Lucía Boiani,Ana Denicola,Carolina Rigol,Lucía Opazo,Claudio Olea-Azar,Juan Diego Maya,Antonio Morello,R Luise Krauth-Siegel,Oscar E. Piro,Eduardo E. Castellano,Mercedes González,Dinorah Gambino,Hugo Cerecetto +14 more
TL;DR: Although the complexes showed strong DNA binding, all data strongly suggest that the main trypanocidal mechanism of action is the production of oxidative stress as a result of their bioreduction and extensive redox cycling.
Journal ArticleDOI
In vitro activity and mechanism of action against the protozoan parasite Trypanosoma cruzi of 5-nitrofuryl containing thiosemicarbazones.
Gabriela Aguirre,Lucía Boiani,Hugo Cerecetto,Marcelo Fernández,Mercedes González,Ana Denicola,Lucía Otero,Dinorah Gambino,Carolina Rigol,Claudio Olea-Azar,Mario Faundez +10 more
TL;DR: The in vitro growth inhibition activity of new thiosemicarbazone derivatives against the protozoan parasite Trypanosoma cruzi, the causative agent of American trypanosomiasis, is described and these compounds are among the most potent 5-nitrofuryl derivatives tested against this parasite.
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New organoruthenium complexes with bioactive thiosemicarbazones as co-ligands: potential anti-trypanosomal agents
Bruno Demoro,Cynthia Sarniguet,Roberto A. Sánchez-Delgado,Miriam Rossi,Daniel Liebowitz,Francesco Caruso,Claudio Olea-Azar,Virtudes Moreno,Andrea Medeiros,Andrea Medeiros,Marcelo A. Comini,Lucía Otero,Dinorah Gambino +12 more
TL;DR: Four ruthenium(II) complexes with the formula [Ru(2)(p-cymene)(2)(L)(2)]X(2), where X = Cl or PF(6), were synthesized and the crystal structures of two of them were solved by X-ray diffraction methods, making them good lead candidates for further developments towards potential antitrypanosomal organometallic drugs.
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Screening organometallic binuclear thiosemicarbazone ruthenium complexes as potential anti-tumour agents: cytotoxic activity and human serum albumin binding mechanism
Bruno Demoro,Rodrigo F.M. de Almeida,Fernanda Marques,Cristina P. Matos,Lucía Otero,João Costa Pessoa,Isabel Santos,Alejandra Rodríguez,Virtudes Moreno,Julia Lorenzo,Dinorah Gambino,Ana Isabel Tomaz +11 more
TL;DR: Results consistently indicate that [Ru2(p-cymene)2(L4)2]Cl2 is quite promising as a prospective metallodrug for cancer chemotherapy.
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Platinum-based complexes of bioactive 3-(5-nitrofuryl)acroleine thiosemicarbazones showing anti-Trypanosoma cruzi activity.
Marisol Vieites,Lucía Otero,Diego Santos,Claudio Olea-Azar,Ester Norambuena,Gabriela Aguirre,Hugo Cerecetto,Mercedes González,Ulrike Kemmerling,Antonio Morello,Juan Diego Maya,Dinorah Gambino +11 more
TL;DR: Eight new platinum(II) complexes with 3-(5-nitrofuryl)acroleine thiosemicarbazones showing anti-trypanosomal activity were synthesized, characterized and in vitro evaluated, showing that some of the compounds could act as dual inhibitors in the parasite, through production of toxic free radicals and interaction with DNA.