Lucía Otero

TL;DR: Although the complexes showed strong DNA binding, all data strongly suggest that the main trypanocidal mechanism of action is the production of oxidative stress as a result of their bioreduction and extensive redox cycling.

TL;DR: The in vitro growth inhibition activity of new thiosemicarbazone derivatives against the protozoan parasite Trypanosoma cruzi, the causative agent of American trypanosomiasis, is described and these compounds are among the most potent 5-nitrofuryl derivatives tested against this parasite.

TL;DR: Four ruthenium(II) complexes with the formula [Ru(2)(p-cymene)(2)(L)(2)]X(2), where X = Cl or PF(6), were synthesized and the crystal structures of two of them were solved by X-ray diffraction methods, making them good lead candidates for further developments towards potential antitrypanosomal organometallic drugs.

TL;DR: Results consistently indicate that [Ru2(p-cymene)2(L4)2]Cl2 is quite promising as a prospective metallodrug for cancer chemotherapy.

TL;DR: Eight new platinum(II) complexes with 3-(5-nitrofuryl)acroleine thiosemicarbazones showing anti-trypanosomal activity were synthesized, characterized and in vitro evaluated, showing that some of the compounds could act as dual inhibitors in the parasite, through production of toxic free radicals and interaction with DNA.