L
Lukas Forer
Researcher at Innsbruck Medical University
Publications - 78
Citations - 11783
Lukas Forer is an academic researcher from Innsbruck Medical University. The author has contributed to research in topics: Medicine & Population. The author has an hindex of 22, co-authored 55 publications receiving 7692 citations. Previous affiliations of Lukas Forer include University of Innsbruck.
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Journal ArticleDOI
Association of mitochondrial DNA copy number with metabolic syndrome and type 2 diabetes in 14 176 individuals.
Federica Fazzini,Claudia Lamina,Athina Raftopoulou,A. Koller,Christian Fuchsberger,Cristian Pattaro,F. M. Del Greco,P. Döttelmayer,Liane Fendt,J. Fritz,J. Fritz,Heike Meiselbach,Sebastian Schönherr,Lukas Forer,Hansi Weissensteiner,Peter P. Pramstaller,Kai-Uwe Eckardt,Kai-Uwe Eckardt,Andrew A. Hicks,Florian Kronenberg +19 more
TL;DR: In this article, the authors investigated the cross-sectional association of mtDNA-CN with type 2 diabetes and the potential mediating role of metabolic syndrome and found that individuals with low mtDNAcopy number had significantly higher odds of Type 2 diabetes (OR 1.025, 95% CI 1.011-1.041; P 2 2.84×10-4 ).
Journal ArticleDOI
Mitochondrial DNA copy number is associated with mortality and infections in a large cohort of patients with chronic kidney disease
Federica Fazzini,Claudia Lamina,Liane Fendt,Ulla T. Schultheiss,Fruzsina Kotsis,Andrew A. Hicks,Heike Meiselbach,Hansi Weissensteiner,Lukas Forer,Vera Krane,Kai-Uwe Eckardt,Kai-Uwe Eckardt,Anna Köttgen,Florian Kronenberg,M. Schneider,Thomas Dienemann,Hans-Ulrich Prokosch,Barbara Bärthlein,Andreas Beck,Thomas Ganslandt,André Reis,Arif B. Ekici,Susanne Avendaño,Dinah Becker-Grosspitsch,Ulrike Alberth-Schmidt,Birgit Hausknecht,Rita Zitzmann,Anke Weigel,Gerd Walz,Ulla T. Schultheiß,Simone Meder,Erna Mitsch,Ursula Reinhard,Jürgen Floege,Georg Schlieper,Turgay Saritas,Sabine Ernst,Nicole Beaujean,Elke Schaeffner,Seema Baid-Agrawal,Kerstin Theisen,Hermann Haller,Jan Menne,Martin Zeier,Claudia Sommerer,Rebecca Woitke,Gunter Wolf,Martin Busch,Rainer Fuß,Thomas Sitter,Claudia Blank,Christoph Wanner,Antje Börner-Klein,Britta Bauer,Julia Raschenberger,Barbara Kollerits,Sebastian Schönherr,Peter J. Oefner,Wolfram Gronwald,Helena U. Zacharias,Matthias Schmid,Jennifer Nadal +61 more
TL;DR: A role of mitochondrial dysfunction in increased cardiovascular disease and mortality risks as well as susceptibility to infections in patients with CKD is supported.
Journal ArticleDOI
Validation of Next-Generation Sequencing of Entire Mitochondrial Genomes and the Diversity of Mitochondrial DNA Mutations in Oral Squamous Cell Carcinoma.
Anita Kloss-Brandstätter,Hansi Weissensteiner,Gertraud Erhart,Georg Schäfer,Lukas Forer,Sebastian Schönherr,Dominic Pacher,Christof Seifarth,Andrea Stöckl,Liane Fendt,Irma Sottsas,Helmut Klocker,Christian W. Huck,Michael Rasse,Florian Kronenberg,Frank Kloss +15 more
TL;DR: The finding of shared mutations between primary tumors, recurrences and metastasis indicates a clonal origin of malignant cells in oral cancer and that NGS is capable of reliably detecting and quantifying heteroplasmies down to the 1%-level.
Journal ArticleDOI
A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response.
Yang Luo,Masahiro Kanai,Wanson Choi,Xinyi Li,Saori Sakaue,Kenichi Yamamoto,Kotaro Ogawa,Maria Gutierrez-Arcelus,Peter K. Gregersen,Philip E. Stuart,James T. Elder,James T. Elder,Lukas Forer,Sebastian Schönherr,Christian Fuchsberger,Albert V. Smith,Jacques Fellay,Jacques Fellay,Mary Carrington,David W Haas,David W Haas,Xiuqing Guo,Nicholette D. Palmer,Yii-Der Ida Chen,Jerome I. Rotter,Kent D. Taylor,Stephen S. Rich,Adolfo Correa,James G. Wilson,Sekar Kathiresan,Sekar Kathiresan,Michael H. Cho,Andres Metspalu,Tõnu Esko,Tõnu Esko,Yukinori Okada,Buhm Han,Paul J. McLaren,Paul J. McLaren,Soumya Raychaudhuri +39 more
TL;DR: In this paper, a reference panel based on whole-genome sequencing data enables accurate imputation of HLA alleles across diverse populations and fine-mapping of association signals for HIV-1 host response.
Journal ArticleDOI
A comprehensive map of single-base polymorphisms in the hypervariable LPA kringle IV type 2 copy number variation region.
Stefan Coassin,Sebastian Schönherr,Hansi Weissensteiner,Gertraud Erhart,Lukas Forer,Jamie Lee Losso,Claudia Lamina,Margot Haun,Gerd Utermann,Bernhard Paulweber,Günther Specht,Florian Kronenberg +11 more
TL;DR: The first map of genetic variation in the KIV-2 region is reported, a comprehensively evaluated ultradeep sequencing protocol, and an easy-to-use variant analysis pipeline are applicable to other similar copy number variable regions, allowing access to regions that are not captured by common genome sequencing.