Y
Yang Luo
Researcher at Brigham and Women's Hospital
Publications - 56
Citations - 6200
Yang Luo is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Population & Human leukocyte antigen. The author has an hindex of 19, co-authored 47 publications receiving 4656 citations. Previous affiliations of Yang Luo include Broad Institute & Medical Research Council.
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Journal ArticleDOI
A reference panel of 64,976 haplotypes for genotype imputation
Shane A. McCarthy,Sayantan Das,Warren W. Kretzschmar,Olivier Delaneau,Andrew R. Wood,Alexander Teumer,Hyun Min Kang,Christian Fuchsberger,Petr Danecek,Kevin Sharp,Yang Luo,C Sidore,Alan Kwong,Nicholas J. Timpson,Seppo Koskinen,Scott I. Vrieze,Laura J. Scott,He Zhang,Anubha Mahajan,Jan H. Veldink,Ulrike Peters,Ulrike Peters,Carlos N. Pato,Cornelia M. van Duijn,Christopher E. Gillies,Ilaria Gandin,Massimo Mezzavilla,Arthur Gilly,Massimiliano Cocca,Michela Traglia,Andrea Angius,Jeffrey C. Barrett,D.I. Boomsma,Kari Branham,Gerome Breen,Gerome Breen,Chad M. Brummett,Fabio Busonero,Harry Campbell,Andrew T. Chan,Sai Chen,Emily Y. Chew,Francis S. Collins,Laura J Corbin,George Davey Smith,George Dedoussis,Marcus Dörr,Aliki-Eleni Farmaki,Luigi Ferrucci,Lukas Forer,Ross M. Fraser,Stacey Gabriel,Shawn Levy,Leif Groop,Leif Groop,Tabitha A. Harrison,Andrew T. Hattersley,Oddgeir L. Holmen,Kristian Hveem,Matthias Kretzler,James Lee,Matt McGue,Thomas Meitinger,David Melzer,Josine L. Min,Karen L. Mohlke,John B. Vincent,Matthias Nauck,Deborah A. Nickerson,Aarno Palotie,Aarno Palotie,Michele T. Pato,Nicola Pirastu,Melvin G. McInnis,J. Brent Richards,J. Brent Richards,Cinzia Sala,Veikko Salomaa,David Schlessinger,Sebastian Schoenherr,P. Eline Slagboom,Kerrin S. Small,Tim D. Spector,Dwight Stambolian,Marcus A. Tuke,Jaakko Tuomilehto,Leonard H. van den Berg,Wouter van Rheenen,Uwe Völker,Cisca Wijmenga,Daniela Toniolo,Eleftheria Zeggini,Paolo Gasparini,Matthew G. Sampson,James F. Wilson,Timothy M. Frayling,Paul I.W. de Bakker,Morris A. Swertz,Steven A. McCarroll,Charles Kooperberg,Annelot M. Dekker,David Altshuler,Cristen J. Willer,William G. Iacono,Samuli Ripatti,Nicole Soranzo,Nicole Soranzo,Klaudia Walter,Anand Swaroop,Francesco Cucca,Carl A. Anderson,Richard M. Myers,Michael Boehnke,Mark I. McCarthy,Mark I. McCarthy,Richard Durbin,Gonçalo R. Abecasis,Jonathan Marchini +117 more
TL;DR: A reference panel of 64,976 human haplotypes at 39,235,157 SNPs constructed using whole-genome sequence data from 20 studies of predominantly European ancestry leads to accurate genotype imputation at minor allele frequencies as low as 0.1% and a large increase in the number of SNPs tested in association studies.
A reference panel of 64,976 haplotypes for genotype imputation
Shane A. McCarthy,Sayantan Das,Warren W. Kretzschmar,Olivier Delaneau,Andrew R. Wood,Alexander Teumer,Hyun Min Kang,Christian Fuchsberger,Petr Danecek,Kevin Sharp,Yang Luo,Carlo Sidorel,Alan Kwong,Nicholas J. Timpson,Seppo Koskinen,Scott I. Vrieze,Laura J. Scott,He Zhang,Anubha Mahajan,Jan H. Veldink,Ulrike Peters,Carlos N. Pato,Cornelia M. van Duijn,Christopher E. Gillies,Ilaria Gandin,Massimo Mezzavilla,Arthur Gilly,Massimiliano Cocca,Michela Traglia,Andrea Angius,Jeffrey C. Barrett,D.I. Boomsma,Kari Branham,Gerome Breen,Chad M. Brummett,Fabio Busonero,Harry Campbell,Andrew T. Chan,Sai Che,Emily Y. Chew,Francis S. Collins,Laura J Corbin,George Davey Smith,George Dedoussis,Marcus Dörr,Aliki-Eleni Farmaki,Luigi Ferrucci,Lukas Forer,Ross M. Fraser,Stacey Gabriel,Shawn Levy,Leif Groop,Tabitha A. Harrison,Andrew T. Hattersley,Oddgeir L. Holmen,Kristian Hveem,Matthias Kretzler,James Lee,Matt McGue,Thomas Meitinger,David Melzer,Josine L. Min,Karen L. Mohlke,John B. Vincent,Matthias Nauck,Deborah A. Nickerson,Aarno Palotie,Michele T. Pato,Nicola Pirastu,Melvin G. McInnis,J. Brent Richards,Cinzia Sala,Veikko Salomaa,David Schlessinger,Sebastian Schoenherr,P. Eline Slagboom,Kerrin S. Small,Tim D. Spector,Dwight Stambolian,Marcus A. Tuke,Jaakko Tuomilehto,Leonard H. van den Berg,Wouter van Rheenen,Uwe Völker,Cisca Wijmenga,Daniela Toniolo,Eleftheria Zeggini,Paolo Gasparini,Matthew G. Sampson,James F. Wilson,Timothy M. Frayling,Paul I.W. de Bakker,Morris A. Swertz,Steven A. McCarroll,Charles Kooperberg,Annelot M. Dekker,David Altshuler,Cristen J. Willer,William G. Iacono,Samuli Ripatti,Nicole Soranzo,Klaudia Walter,Anand Swaroop,Francesco Cucca,Carl A. Anderson,Richard M. Myers,Michael Boehnke,Mark I. McCarthy,Richard Durbin,Gonçalo R. Abecasis,Jonathan Marchini +110 more
TL;DR: In this article, a reference panel of 64,976 human haplotypes at 39,235,157 SNPs constructed using whole-genome sequence data from 20 studies of predominantly European ancestry is presented.
Journal ArticleDOI
Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease
Katrina M. de Lange,Loukas Moutsianas,James Lee,Christopher A. Lamb,Yang Luo,Yang Luo,Yang Luo,Nicholas A. Kennedy,Luke Jostins,Luke Jostins,Daniel L. Rice,Javier Gutierrez-Achury,Sun-Gou Ji,Graham A. Heap,Elaine R. Nimmo,Cathryn Edwards,Paul Henderson,Paul Henderson,Craig Mowat,Jeremy D. Sanderson,Jack Satsangi,Alison Simmons,Alison Simmons,David C. Wilson,David C. Wilson,Mark Tremelling,Ailsa Hart,Christopher G. Mathew,Christopher G. Mathew,William G. Newman,William G. Newman,Miles Parkes,Charlie W. Lees,Holm H. Uhlig,Christopher J. Hawkey,Natalie J. Prescott,Tariq Ahmad,John C. Mansfield,Carl A. Anderson,Jeffrey C. Barrett +39 more
TL;DR: This work identified 25 new susceptibility loci, 3 of which contain integrin genes that encode proteins in pathways that have been identified as important therapeutic targets in inflammatory bowel disease and identified 3 associated variants that are correlated with expression changes in response to immune stimulus at two of these genes.
Journal ArticleDOI
Genesis, Evolution and Prevalence of H5N6 Avian Influenza Viruses in China
Yuhai Bi,Quanjiao Chen,Qianli Wang,Jianjun Chen,Tao Jin,Gary Wong,Chuansong Quan,Jun Liu,Jun Wu,Renfu Yin,Lihua Zhao,Mingxin Li,Zhuang Ding,Rongrong Zou,Wen Xu,Hong Li,Huijun Wang,Kegong Tian,Guanghua Fu,Yu Huang,Alexander Shestopalov,Shoujun Li,Bing Xu,Hongjie Yu,Tingrong Luo,Lin Lu,Xun Xu,Yang Luo,Yingxia Liu,Weifeng Shi,Di Liu,George F. Gao +31 more
TL;DR: Phylogenetic analysis reveals that H5N6 arose from reassortments of H5 and H6N6 viruses, with the hemagglutinin and neuraminidase combinations being strongly lineage specific.
Journal ArticleDOI
Genetic diversity and evolutionary dynamics of Ebola virus in Sierra Leone
Yigang Tong,Weifeng Shi,Di Liu,Jun Qian,Long Liang,Xiaochen Bo,Jun Liu,Hong-Guang Ren,Hang Fan,Ming Ni,Yang Sun,Yuan Jin,Yue Teng,Zhen Li,David Kargbo,Foday Dafae,Alex Kanu,Cheng-Chao Chen,Zhi-Heng Lan,Hui Jiang,Yang Luo,Hui-Jun Lu,Xiao-Guang Zhang,Fan Yang,Yi Hu,Yuxi Cao,Yong-Qiang Deng,Haoxiang Su,Yu Sun,Liu Wensen,Zhuang Wang,Cheng-Yu Wang,Zhao-Yang Bu,Zhen-Dong Guo,Liu-Bo Zhang,Wei-Min Nie,Changqing Bai,Chun-Hua Sun,Xiaoping An,Peisong Xu,Xianglilan Zhang,Yong Huang,Zhiqiang Mi,Dong Yu,Hong-Wu Yao,Yong Feng,Zhiping Xia,Xuexing Zheng,Songtao Yang,Bing Lu,Jia-Fu Jiang,Brima Kargbo,Fu-Chu He,George F. Gao,Wu-Chun Cao +54 more
TL;DR: The 2014 Ebola virus has become more phylogenetically and genetically diverse from July to November 2014, characterized by the emergence of multiple novel lineages and the sharp increase in genetic diversity of the 2014 EBOV.