B
Bryan D. Young
Researcher at Queen Mary University of London
Publications - 72
Citations - 4306
Bryan D. Young is an academic researcher from Queen Mary University of London. The author has contributed to research in topics: Cancer & Gene. The author has an hindex of 33, co-authored 72 publications receiving 4044 citations. Previous affiliations of Bryan D. Young include London Research Institute & St Bartholomew's Hospital.
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Journal ArticleDOI
Mutations in ABCA12 underlie the severe congenital skin disease harlequin ichthyosis.
David P. Kelsell,Elizabeth E. Norgett,H Unsworth,Muy-Teck Teh,Thomas Cullup,Charles A. Mein,Patricia J.C. Dopping-Hepenstal,Beverly A. Dale,Gianluca Tadini,Philip Fleckman,Karen Stephens,Virginia P. Sybert,Susan B. Mallory,Bernard V. North,David R. Witt,Eli Sprecher,Aileen Taylor,Andrew Ilchyshyn,Cameron T. C. Kennedy,Helen Goodyear,Celia Moss,D. Paige,John I. Harper,Bryan D. Young,Irene M. Leigh,Robin A.J. Eady,Edel A. O'Toole +26 more
TL;DR: Sequencing of the ABCA12 gene revealed disease-associated mutations, including large intragenic deletions and frameshift deletions in 11 of the 12 screened individuals with HI, which paves the way for early prenatal diagnosis and leads to a better understanding of epidermal differentiation and barrier formation.
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Distinctive patterns of microRNA expression associated with karyotype in acute myeloid leukaemia.
Amanda Dixon-McIver,Phil East,Charles A. Mein,Jean-Baptiste Cazier,Gael Molloy,Tracy Chaplin,T. Andrew Lister,Bryan D. Young,Silvana Debernardi +8 more
TL;DR: The potential for using miRNA expression to sub-classify cancer and suggest a role in the aetiology of leukaemia is demonstrated and the role of miRNAs in this disease is suggested.
Journal ArticleDOI
Activation of the ERK/MAPK pathway: a signature genetic defect in posterior fossa pilocytic astrocytomas.
Tim Forshew,Ruth G. Tatevossian,Ruth G. Tatevossian,Andrew R. J. Lawson,Jing Ma,Geoff Neale,Babatunji W Ogunkolade,Tania A. Jones,Johan Aarum,James Dalton,Simon Bailey,Tracy Chaplin,Rowena L Carter,Amar Gajjar,Alberto Broniscer,Bryan D. Young,David W. Ellison,Denise Sheer +17 more
TL;DR: Genetic aberrations that activate the ERK/MAP kinase pathway in 100% of posterior fossa pilocytic astrocytomas are reported, with a high frequency of gene fusions between KIAA1549 and BRAF among these tumours.
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MicroRNA miR-181a correlates with morphological sub-class of acute myeloid leukaemia and the expression of its target genes in global genome-wide analysis.
Silvana Debernardi,Spyros Skoulakis,Gael Molloy,Tracy Chaplin,Amanda Dixon-McIver,Bryan D. Young +5 more
TL;DR: Estimation of expression levels of a selected group of haematopoietic tissue-specific miRNAs revealed that miR-181a correlated strongly with the AML morphological sub-type and with the expression of genes previously identified through sequence analysis as potential interaction targets.
Journal ArticleDOI
AML engraftment in the NOD/SCID assay reflects the outcome of AML: implications for our understanding of the heterogeneity of AML
Daniel J. Pearce,David Taussig,David Taussig,David Taussig,Kazem Zibara,Kazem Zibara,Kazem Zibara,Lan-Lan Smith,Lan-Lan Smith,Lan-Lan Smith,Christopher M. Ridler,Christopher M. Ridler,Christopher M. Ridler,Claude Preudhomme,Claude Preudhomme,Claude Preudhomme,Bryan D. Young,Bryan D. Young,Bryan D. Young,Ama Z. S. Rohatiner,Ama Z. S. Rohatiner,Ama Z. S. Rohatiner,T. Andrew Lister,T. Andrew Lister,T. Andrew Lister,Dominique Bonnet,Dominique Bonnet,Dominique Bonnet +27 more
TL;DR: The ability of AML to engraft in the NOD/SCID assay seems to be an inherent property of AMl cells, independent of homing, conditioning, or cell frequency/source, which is directly related to prognosis.