Magda E. Lotkowska

TL;DR: Transcriptomic analysis together with cytokine and immune cell profiling of peripheral blood can robustly detect immune differences between children with different numbers of prior malaria episodes, and observe that multiple episodes of malaria are associated with modification of the immune system.

TL;DR: Further optimisation of CRISPR-Cas protocols for different developmental stages and particular cell types will contribute to the generation of a homozygous knock-out in any gene of interest, and in particular the SULT-OR gene to derive an oxamniquine-resistant stable transgenic line.

TL;DR: In this paper, the authors explored the interaction between inflammation and parasite variant surface antigen (VSA) expression, asking whether this relationship underpins the variation observed in controlled human malaria infection (CHMI).

TL;DR: This work reinforces the importance of adequate surveillance of both human and dog populations in the Guinea worm eradication campaign and suggests that control programs aiming to interrupt disease transmission should stay aware of the possible emergence of unusual epidemiology as pathogens approach elimination.

TL;DR: In this article, the authors have sequenced and compared the genomes of worms from dog, human and other animal infections, and confirmed that all worms are D. medinensis, and that the same population of worms are causing both infections, can confirm the suspected transmission between host species and detect signs of a population bottleneck due to the eradication efforts.