Z
Zahra Abdellah
Researcher at Wellcome Trust Sanger Institute
Publications - 9
Citations - 1674
Zahra Abdellah is an academic researcher from Wellcome Trust Sanger Institute. The author has contributed to research in topics: Genome & Mycobacterium tuberculosis. The author has an hindex of 6, co-authored 9 publications receiving 1518 citations.
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Journal ArticleDOI
Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis
Timothy P. Stinear,Torsten Seemann,Paul Harrison,Grant A. Jenkin,John K. Davies,Paul D R Johnson,Zahra Abdellah,Claire Arrowsmith,Tracey Chillingworth,Carol Churcher,Kay Clarke,Ann Cronin,Paul Davis,Ian Goodhead,Nancy Holroyd,Kay Jagels,Angela Lord,Sharon Moule,Karen Mungall,Halina Norbertczak,Michael A. Quail,Ester Rabbinowitsch,Danielle Walker,Brian White,Sally Whitehead,Pamela L. C. Small,Roland Brosch,Lalita Ramakrishnan,Michael A. Fischbach,Julian Parkhill,Stewart T. Cole +30 more
TL;DR: The genome of the M strain of M. marinum comprises a 6,636,827-bp circular chromosome with 5424 CDS, 10 prophages, and a 23-kb mercury-resistance plasmid as discussed by the authors.
Journal ArticleDOI
Comparative genome analysis of Salmonella Enteritidis PT4 and Salmonella Gallinarum 287/91 provides insights into evolutionary and host adaptation pathways.
Nicholas R. Thomson,Debra J. Clayton,Daniel Windhorst,Georgios S. Vernikos,Susanne Davidson,Carol Churcher,Michael A. Quail,Mark P. Stevens,Michael Jones,Michael Watson,Andy Barron,Abigail N. Layton,Derek Pickard,Robert A. Kingsley,Alex Bignell,Louise Clark,Barbara Harris,Doug Ormond,Zahra Abdellah,Karen Brooks,Inna Cherevach,Tracey Chillingworth,John Woodward,Halina Norberczak,Angela Lord,Claire Arrowsmith,Kay Jagels,Sharon Moule,Karen Mungall,Mandy Sanders,Sally Whitehead,José A. Chabalgoity,Duncan J. Maskell,Tom J. Humphrey,Mark Roberts,Paul A. Barrow,Gordon Dougan,Julian Parkhill +37 more
TL;DR: Genome comparisons between these and other Salmonella isolates indicate that S. Gallinarum 287/91 is a recently evolved descendent of S. Enteritidis, and it is proposed that experimental analysis in chickens and mice could provide an experimentally tractable route toward unraveling the genetic basis of host adaptation in S. enterica.
Journal ArticleDOI
Complete Genome Sequence of Uropathogenic Proteus mirabilis, a Master of both Adherence and Motility
Melanie M. Pearson,Mohammed Sebaihia,Carol Churcher,Michael A. Quail,Aswin Sai Narain Seshasayee,Nicholas M. Luscombe,Zahra Abdellah,Claire Arrosmith,Becky Atkin,Tracey Chillingworth,Heidi Hauser,Kay Jagels,Sharon Moule,Karen Mungall,Halina Norbertczak,Ester Rabbinowitsch,Danielle Walker,Sally Whithead,Nicholas R. Thomson,Philip N. Rather,Julian Parkhill,Harry L. T. Mobley +21 more
TL;DR: The complete genome sequence of P. mirabilis HI4320 is reported, a representative strain cultured in the laboratory from the urine of a nursing home patient with a long-term (> or =30 days) indwelling urinary catheter.
Journal ArticleDOI
The complete genome sequence and comparative genome analysis of the high pathogenicity Yersinia enterocolitica strain 8081.
Nicholas R. Thomson,Sarah L. Howard,Brendan W. Wren,Matthew T. G. Holden,Lisa Crossman,Gregory L. Challis,Carol Churcher,Karen Mungall,Karen Brooks,Tracey Chillingworth,Theresa Feltwell,Zahra Abdellah,Heidi Hauser,Kay Jagels,Mark Maddison,Sharon Moule,Mandy Sanders,Sally Whitehead,Michael A. Quail,Gordon Dougan,Julian Parkhill,Michael B. Prentice +21 more
TL;DR: The analysis reveals that the genome of Y. enterocolitica strain 8081 is a patchwork of horizontally acquired genetic loci, including a plasticity zone of 199 kb containing an extraordinarily high density of virulence genes, indicating major differences in niche and nutrients used within the mammalian gut.
Journal ArticleDOI
Human Y Chromosome Base-Substitution Mutation Rate Measured by Direct Sequencing in a Deep-Rooting Pedigree
Yali Xue,Qiuju Wang,Quan Long,Bee Ling Ng,Harold Swerdlow,John Burton,C. D. Skuce,Ruth Taylor,Zahra Abdellah,Yali Zhao,Daniel G. MacArthur,Michael A. Quail,Nigel P. Carter,Huanming Yang,Chris Tyler-Smith +14 more
TL;DR: New sequencing technology is applied to measure directly one mutation rate, that of base substitutions on the human Y chromosome, which is important for many aspects of medical genetics and human evolution.