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Caroline Durrant
Researcher at Wellcome Trust Sanger Institute
Publications - 29
Citations - 2960
Caroline Durrant is an academic researcher from Wellcome Trust Sanger Institute. The author has contributed to research in topics: Population & Quantitative trait locus. The author has an hindex of 16, co-authored 29 publications receiving 2683 citations. Previous affiliations of Caroline Durrant include University of Oxford & Wellcome Trust Centre for Human Genetics.
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Journal ArticleDOI
A Multiparent Advanced Generation Inter-Cross to Fine-Map Quantitative Traits in Arabidopsis thaliana
Paula X. Kover,Paula X. Kover,William Valdar,Joseph Trakalo,Nora Scarcelli,Ian M. Ehrenreich,Michael D. Purugganan,Caroline Durrant,Richard Mott +8 more
TL;DR: The first panel of MAGIC lines developed is presented, a set of 527 recombinant inbred lines descended from a heterogeneous stock of 19 intermated accessions of the plant Arabidopsis thaliana, and it is shown how the power to detect a QTL and the mapping accuracy vary, depending on QTL location.
Journal ArticleDOI
Gene X environment interactions at the serotonin transporter locus.
TL;DR: A systematic review and meta-analysis of the serotonin transporter (5-HTTLPR) polymorphic region x stressful life event (SLE) literature and investigated to what extent the main effects reported in this literature are consistent with a number of G x E hypotheses indicates that published studies are underpowered.
Journal ArticleDOI
The genome architecture of the collaborative cross mouse genetic reference population
Fuad A. Iraqi,Mustafa Mahajne,Yasser Salaymah,Hani Sandovski,Hanna Tayem,Karin Vered,Lois Balmer,Michael R. Hall,Glynn Manship,Grant Morahan,Ken Pettit,Jeremy Scholten,Kathryn Tweedie,Andrew Wallace,Lakshini Weerasekera,James Cleak,Caroline Durrant,Leo Goodstadt,Richard Mott,Binnaz Yalcin,David L. Aylor,Ralph S. Baric,Timothy A. Bell,Katharine M. Bendt,J. Brennan,Jackie D. Brooks,Ryan J. Buus,James J. Crowley,John D. Calaway,Mark Calaway,Agnieszka Cholka,David B. Darr,John P. Didion,Amy Dorman,Eric T. Everett,Martin T. Ferris,Wendy Foulds Mathes,Chen Ping Fu,Terry J. Gooch,Summer G. Goodson,Lisa E. Gralinski,Stephanie D. Hansen,Mark T. Heise,Jane Hoel,Kunjie Hua,Mayanga C. Kapita,Seunggeun Lee,Alan B. Lenarcic,Eric Yi Liu,Hedi Liu,Leonard McMillan,Terry Magnuson,Kenneth F. Manly,Darla R. Miller,Deborah A. O'Brien,Fanny Odet,Isa Kemal Pakatci,Wenqi Pan,Fernando Pardo-Manuel de Villena,Charles M. Perou,Daniel Pomp,Corey R. Quackenbush,Nashiya N. Robinson,Norman E. Sharpless,Ginger D. Shaw,Jason S. Spence,Patrick F. Sullivan,Wei Sun,Lisa M. Tarantino,William Valdar,Jeremy Wang,Wei Wang,Catherine E. Welsh,Alan C. Whitmore,Tim Wiltshire,Fred A. Wright,Yuying Xie,Zaining Yun,Vasyl Zhabotynsky,Zhaojun Zhang,Fei Zou,Christine L. Powell,Jill Steigerwalt,David W. Threadgill,Elissa J. Chesler,Gary A. Churchill,Daniel M. Gatti,Ron Korstanje,Karen L. Svenson,Francis S. Collins,Nigel P.S. Crawford,Kent W. Hunter,N. Samir,P. Kelada,Bailey C.E. Peck,Karlyne M. Reilly,Urraca Tavarez,Daniel Bottomly,Robert Hitzeman,Shannon K. McWeeney,Jeffrey A. Frelinger,Harsha Krovi,Jason Phillippi,Richard A. Spritz,Lauri D. Aicher,Michael G. Katze,Elizabeth Rosenzweig,Ariel Shusterman,Aysar Nashef,Ervin I. Weiss,Yael Houri-Haddad,Morris Soller,Robert W. Williams,Klaus Schughart,Hyuna Yang,John E. French,Andrew K. Benson,Jaehyoung Kim,Ryan Legge,Soo Jen Low,Fangrui Ma,Inés Martínez,Jens Walter,Karl W. Broman,Benedikt Hallgrímsson,Ophir D. Klein,George M. Weinstock,Wesley C. Warren,Yvana V. Yang,David A. Schwartz +129 more
TL;DR: The Collaborative Cross Consortium reports here on the development of a unique genetic resource population, a multiparental recombinant inbred panel derived from eight laboratory mouse inbred strains, which shows that founder haplotypes are inherited at the expected frequency.
Journal ArticleDOI
Genetic analysis of complex traits in the emerging Collaborative Cross
David L. Aylor,William Valdar,Wendy Foulds-Mathes,Ryan J. Buus,Ricardo A. Verdugo,Ralph S. Baric,Martin T. Ferris,Jeffrey A. Frelinger,Mark T. Heise,Matthew B. Frieman,Lisa E. Gralinski,Timothy A. Bell,John D. Didion,Kunjie Hua,Derrick L. Nehrenberg,Christine L. Powell,Jill Steigerwalt,Yuying Xie,Samir N. P. Kelada,Francis S. Collins,Ivana V. Yang,David A. Schwartz,Lisa A. Branstetter,Elissa J. Chesler,Darla R. Miller,Jason S. Spence,Eric Yi Liu,Leonard McMillan,Abhishek Sarkar,Jeremy Wang,Wei Wang,Qi Zhang,Karl W. Broman,Ron Korstanje,Caroline Durrant,Richard Mott,Fuad A. Iraqi,Daniel Pomp,David W. Threadgill,Fernando Pardo-Manuel de Villena,Gary A. Churchill +40 more
TL;DR: It is demonstrated that the genetic diversity of the CC, which derives from random mixing of eight founder strains, results in high phenotypic diversity and enhances the ability to map causative loci underlying complex disease-related traits.
Journal ArticleDOI
Linkage Disequilibrium Mapping via Cladistic Analysis of Single-Nucleotide Polymorphism Haplotypes
Caroline Durrant,Krina T. Zondervan,Lon R. Cardon,Sarah E. Hunt,Panos Deloukas,Andrew P. Morris +5 more
TL;DR: A simulation algorithm is developed to generate high-density SNP data with short-range linkage disequilibrium based on empirical patterns of haplotype diversity that highlights substantial gains in power over single-locus tests for a wide range of disease models, despite overcorrection for multiple testing.