M
Mahendrasingh Ramjeet
Researcher at University of Toronto
Publications - 3
Citations - 1384
Mahendrasingh Ramjeet is an academic researcher from University of Toronto. The author has contributed to research in topics: Autophagy & ATG16L1. The author has an hindex of 3, co-authored 3 publications receiving 1264 citations.
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Journal ArticleDOI
Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry
Leonardo H. Travassos,Leticia A.M. Carneiro,Mahendrasingh Ramjeet,Seamus Hussey,Seamus Hussey,Yun Gi Kim,Joao G. Magalhaes,Linda Yuan,Fraser Soares,Evelyn Chea,Lionel Le Bourhis,Ivo G Boneca,Abdelmounaaim Allaoui,Nicola L. Jones,Gabriel Núñez,Stephen E. Girardin,Dana J. Philpott +16 more
TL;DR: The results link bacterial sensing by Nod proteins to the induction of autophagy and provide a functional link between Nod2 and ATG16L1, which are encoded by two of the most important genes associated with Crohn's disease.
Journal ArticleDOI
The Protein ATG16L1 Suppresses Inflammatory Cytokines Induced by the Intracellular Sensors Nod1 and Nod2 in an Autophagy-Independent Manner
Matthew T. Sorbara,Lisa K. Ellison,Mahendrasingh Ramjeet,Leonardo H. Travassos,Nicola L. Jones,Stephen E. Girardin,Dana J. Philpott +6 more
TL;DR: It is suggested that ATG16L1 is critical for Nod-dependent regulation of cytokine responses and that disruption of this Nod1- or Nod2-ATG 16L1 signaling axis could contribute to the chronic inflammation associated with CD.
Journal ArticleDOI
'Nodophagy': New cross-roads in Crohn's disease pathogenesis
TL;DR: A homeostatic pathway that processes and recycles damaged organelles and other cytoplasmic contents and its role in the immune response to infection is implicated.