T
Takayuki Ishikawa
Researcher at Kyoto University
Publications - 205
Citations - 3662
Takayuki Ishikawa is an academic researcher from Kyoto University. The author has contributed to research in topics: Transplantation & Hematopoietic stem cell transplantation. The author has an hindex of 27, co-authored 205 publications receiving 2844 citations.
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Journal ArticleDOI
The Human OX40/gp34 System Directly Mediates Adhesion of Activated T Cells to Vascular Endothelial Cells
Akihiro Imura,Toshiyuki Hori,Kazunori Imada,Takayuki Ishikawa,Yoshimasa Tanaka,Michiyuki Maeda,Sadao Imamura,Takashi Uchiyama +7 more
TL;DR: Results indicate that the OX40/gp34 system directly mediates adhesion of activated T cells or Ox40+-transformed T cells to vascular endothelial cells.
Journal ArticleDOI
Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes
Elsa Bernard,Yasuhito Nannya,Robert P. Hasserjian,Sean M. Devlin,Heinz Tuechler,Juan S. Medina-Martinez,Tetsuichi Yoshizato,Yusuke Shiozawa,Ryunosuke Saiki,Luca Malcovati,Max Levine,Juan E. Arango,Yangyu Zhou,Francesc Solé,Catherine Cargo,Detlef Haase,Maria Creignou,Ulrich Germing,Yanming Zhang,Gunes Gundem,Araxe Sarian,Arjan A. van de Loosdrecht,Martin Jädersten,Magnus Tobiasson,Olivier Kosmider,Matilde Y. Follo,Felicitas Thol,Ronald Feitosa Pinheiro,Valeria Santini,Ioannis Kotsianidis,Jacqueline Boultwood,Fabio P.S. Santos,Julie Schanz,Senji Kasahara,Takayuki Ishikawa,Hisashi Tsurumi,Akifumi Takaori-Kondo,Toru Kiguchi,Chantana Polprasert,John M. Bennett,Virginia M. Klimek,Michael R. Savona,Monika Belickova,Christina Ganster,Laura Palomo,Guillermo Sanz,Lionel Ades,Matteo G. Della Porta,Alexandra Smith,Yesenia Werner,Minal Patel,Agnes Viale,Katelynd Vanness,Donna Neuberg,Kristen E. Stevenson,Kamal Menghrajani,Kelly L. Bolton,Pierre Fenaux,Andrea Pellagatti,Uwe Platzbecker,Michael Heuser,Peter Valent,Shigeru Chiba,Yasushi Miyazaki,Carlo Finelli,Maria Teresa Voso,Lee Yung Shih,Michaela Fontenay,Joop H. Jansen,José Cervera,Yoshiko Atsuta,Norbert Gattermann,Benjamin L. Ebert,Rafael Bejar,Peter L. Greenberg,Mario Cazzola,Eva Hellström-Lindberg,Seishi Ogawa,Elli Papaemmanuil +78 more
TL;DR: Clinical sequencing across a large prospective cohort of patients with myelodysplasic syndrome uncovers distinct associations between the mono- and biallelic states of TP53 and clinical presentation.
Journal ArticleDOI
Down-regulation of hepcidin resulting from long-term treatment with an anti–IL-6 receptor antibody (tocilizumab) improves anemia of inflammation in multicentric Castleman disease
Soken-Nakazawa J. Song,Naohisa Tomosugi,Hiroshi Kawabata,Takayuki Ishikawa,Teppei Nishikawa,Kazuyuki Yoshizaki +5 more
TL;DR: It is found that tocilizumab treatment resulted in a rapid reduction of serum hepcidin-25 in 5 of 6 MCD patients, and IL-6 plays an essential role in the induction of hePCidin in MCD.
Journal ArticleDOI
Oral ixazomib maintenance following autologous stem cell transplantation (TOURMALINE-MM3): a double-blind, randomised, placebo-controlled phase 3 trial
Meletios A. Dimopoulos,Fredrik Schjesvold,Fredrik Schjesvold,Meral Beksac,Roman Hájek,Katja Weisel,Hartmut Goldschmidt,Vladimir Maisnar,Philippe Moreau,Chang-Ki Min,Agnieszka Pluta,Wee Joo Chng,Martin Kaiser,Martin Kaiser,Sonja Zweegman,Maria-Victoria Mateos,Andrew Spencer,Shinsuke Iida,Gareth J. Morgan,Kaveri Suryanarayan,Zhaoyang Teng,Tomas Skacel,Antonio Palumbo,Antonio Palumbo,Antonio Palumbo,Ajeeta B Dash,Neeraj Gupta,Richard Labotka,S. Vincent Rajkumar,Daniel Bar,Alfredo Basso,Dorotea Fantl,Simon He,Neomi Horvath,Cindy Lee,Phillip Rowlings,Kerry Taylor,Tara Cochrane,Fiona Kwok,Sundreswran Ramanathan,Hermine Agis,Niklas Zojer,Alain Kentos,Fritz Offner,Jan Van Droogenbroeck,Ka Lung Wu,Angelo Maiolino,Gracia Martinez,Karla Zanella,Marcelo Capra,Sergio Eduardo Alonso Araujo,Evzen Gregora,Ludek Pour,Vlastimil Scudla,Ivan Spicka,Niels Abildgaard,Niels Holmark Andersen,Bo Amdi Jensen,Carsten Helleberg,Torben Plesner,Morten Salomo,Asta Svirskaite,Richard Delarue,Igor Wolfgang Blau,Aneta Schieferdecker,Veronica Teleanu,Markus Munder,Christoph Röllig,Han-Juergen Salwender,Stephan Fuhrmann,Katja Weisel,Jan Duerig,Matthias Zeis,Stefan Klein,Peter Reimer,Christian Schmidt,Christof Scheid,Karin Mayer,Martin Hoffmann,Markus Sosada,Athanasios Dimopoulos,Sosana Delimpasi,Mary-Christine Kyrtsonis,Achilleas Anagnostopoulos,Zsolt Nagy,Árpád Illés,Miklos Egyed,Zita Borbényi,Gabor Mikala,Najib Dally,Netanel Horowitz,Odit Gutwein,Anatoly Nemets,Iuliana Vaxman,Olga Shvetz,Svetlana Trestman,Rosa Ruchlemer,Arnon Nagler,Tamar Tadmor,Ory Rouvio,Meir Preis,Michele Cavo,Luca De Rosa,Pellegrino Musto,Anna Maria Cafro,Patrizia Tosi,Massimo Offidani,Alessandro Corso,Giuseppe Rossi,Anna Marina Liberati,Alberto Bosi,Kenshi Suzuki,Chiaki Nakaseko,Takayuki Ishikawa,Morio Matsumoto,Hirokazu Nagai,Kazutaka Sunami,Takaaki Chou,Koichi Akashi,Naoki Takezako,Shotaro Hagiwara,Hyeon Seok Eom,Deog-Yeon Jo,Jin Seok Kim,Jae Hoon Lee,Sung-Soo Yoon,Dok Hyun Yoon,Kihyun Kim,Mark-David Levin,Edo Vellenga,Monique C. Minnema,Anders Waage,Einar Haukås,Sebastian Grosicki,Andrzej Pluta,Tadeusz Robak,Herlander Marques,Rui Bergantim,Fernando Campilho,Wee Joo Chng,Yeow Tee Goh,Andrew McDonald,Bernado Rapoport,Miguel Angel Álvarez Rivas,Felipe de Arriba de la Fuente,Yolanda González Montes,Jesus Martin Sanchez,María-Victoria Mateos,Albert Oriol Rocafiguera,Laura Rosiñol,Jesús F. San Miguel,Jaime Pérez de Oteyza,Cristina Encinas,Adrian Alegre-Amor,Ana López-Guía,Per Axelsson,Kristina Carlson,Olga Stromberg,Markus Hansson,Cecile Hveding Blimark,Rouven Mueller,Chih-Cheng Chen,Ta-Chih Liu,Shang-Yi Huang,Po-Nan Wang,Thanyaphong Na Nakorn,Kannadit Prayongratana,Ali Ünal,Hakan Goker,Mehmet Sönmez,Sybiryna Korenkova,Aristeidis Chaidos,Heather Oakervee,Hamdi Sati,Reuben Benjamin,Ashutosh D. Wechalekar,Mamta Garg,Karthik Ramasamy,Gordon Cook,Andrew D Chantry,Matthew W Jenner,Francis K. Buadi,Robert Berryman,Murali Janakiram +183 more
TL;DR: Ixazomib maintenance prolongs PFS and represents an additional option for post-transplant maintenance therapy in patients with newly diagnosed multiple myeloma.
Journal ArticleDOI
Molecular heterogeneity in peripheral T-cell lymphoma, not otherwise specified revealed by comprehensive genetic profiling
Yosaku Watatani,Yasuharu Sato,Yasuharu Sato,Hiroaki Miyoshi,Kana Sakamoto,Kenji Nishida,Yuka Gion,Yasunobu Nagata,Yuichi Shiraishi,Kenichi Chiba,Hiroko Tanaka,Lanying Zhao,Yotaro Ochi,Yasuhide Takeuchi,June Takeda,Hiroo Ueno,Yasunori Kogure,Yusuke Shiozawa,Nobuyuki Kakiuchi,Tetsuichi Yoshizato,Masahiro Nakagawa,Yasuhito Nanya,Kenichi Yoshida,Hideki Makishima,Masashi Sanada,Mamiko Sakata-Yanagimoto,Shigeru Chiba,Ryota Matsuoka,Masayuki Noguchi,Nobuhiro Hiramoto,Takayuki Ishikawa,Junichi Kitagawa,Nobuhiko Nakamura,Hisashi Tsurumi,Tatsuhiko Miyazaki,Yusuke Kito,Satoru Miyano,Kazuya Shimoda,Kengo Takeuchi,Koichi Ohshima,Tadashi Yoshino,Seishi Ogawa,Keisuke Kataoka +42 more
TL;DR: Combining whole-exome and targeted-capture sequencing, gene-expression profiling, and immunohistochemical analysis of tumor samples from 133 cases, this work delineated the entire landscape of somatic alterations, and discovered frequently affected driver pathways in PTCL, NOS, with and without a T-follicular helper (TFH) cell phenotype.