M
Marc C. Levesque
Researcher at Duke University
Publications - 61
Citations - 2965
Marc C. Levesque is an academic researcher from Duke University. The author has contributed to research in topics: Chronic lymphocytic leukemia & Nitric oxide synthase. The author has an hindex of 31, co-authored 58 publications receiving 2744 citations. Previous affiliations of Marc C. Levesque include University of Pittsburgh & Dartmouth College.
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Journal ArticleDOI
High-throughput isolation of immunoglobulin genes from single human B cells and expression as monoclonal antibodies.
Hua-Xin Liao,Marc C. Levesque,Ashleigh Nagel,Ashlyn Dixon,Ruijun Zhang,Emmanuel B. Walter,Robert Parks,John Whitesides,Dawn J. Marshall,Kwan-Ki Hwang,Yi Yang,Xi Chen,Feng Gao,Supriya Munshaw,Thomas B. Kepler,Thomas N. Denny,M. Anthony Moody,Barton F. Haynes +17 more
TL;DR: Novel linear Ig heavy- and light-chain gene expression cassettes were designed to express Ig V(H) and V(L) genes isolated from sorted single B cells as IgG1 antibody without a cloning step to constitute a highly efficient strategy for rapid expression of Ig genes for high-throughput screening and analysis without cloning.
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Treatment of Lupus Nephritis with Abatacept: The Abatacept and Cyclophosphamide Combination Efficacy and Safety Study
Anca Askanase,Margie Byron,Lynette Keyes-Elstein,Patricia Cagnoli,W. Joseph McCune,W. Winn Chatham,Gabriel Contreras,David I. Daikh,Maria Dall'Era,David Wofsy,Anne Davidson,Betty Diamond,Meggan Mackay,Linna Ding,Wendy Gao,Mary Anne Dooley,Hilda Fragoso-Loyo,Jorge Sánchez-Guerrero,David R. Karp,Nancy J. Olsen,Meenakshi Jolly,Kenneth C. Kalunian,Diane L. Kamen,Iris Lee,Marc C. Levesque,S. Sam Lim,Cesar Ramos-Remus,Brad H. Rovin,Peter H. Sayre,Dawn E. Smilek,Patti Tosta,Tammy O. Utset,Swamy Venuturupalli,Robert Winchester +33 more
TL;DR: The potential of abatacept to induce “clinical tolerance,” defined as sustained clinical quiescence of lupus nephritis after discontinuation of immunosuppressive therapy, is assessed.
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A new NOS2 promoter polymorphism associated with increased nitric oxide production and protection from severe malaria in Tanzanian and Kenyan children
Maurine R. Hobbs,Venkatachalam Udhayakumar,Marc C. Levesque,Jennifer Booth,Jacquelin M. Roberts,Ariana N. Tkachuk,Ann Pole,Hilary Coon,Simon Kariuki,Bernard L. Nahlen,Esther D. Mwaikambo,Altaf L Lal,Donald L. Granger,Nicholas M. Anstey,J. Brice Weinberg +14 more
TL;DR: Increased NO production in individuals with the NOS2 promoter -1173 C-->T single nucleotide polymorphism lends support to a protective role for NO against these syndromes.
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Polyclonal B cell differentiation and loss of gastrointestinal tract germinal centers in the earliest stages of HIV-1 infection.
Marc C. Levesque,M. Anthony Moody,Kwan Ki Hwang,Dawn J. Marshall,John F. Whitesides,Joshua D. Amos,Thaddeus C. Gurley,Sallie D. Allgood,Benjamin B. Haynes,Nathan Vandergrift,Steven G. Plonk,Daniel C. Parker,Myron S. Cohen,Georgia D. Tomaras,Paul A. Goepfert,George M. Shaw,Jörn E. Schmitz,Joseph J. Eron,Nicholas J. Shaheen,Charles B. Hicks,Hua-Xin Liao,Martin Markowitz,Garnett Kelsoe,David M. Margolis,Barton F. Haynes +24 more
TL;DR: Studying the effects of early HIV infection on human antibody responses, M. Anthony Moody and colleagues find rapid polyclonal B cell differentiation and structural damage to gut-associated lymphoid tissue.
Journal ArticleDOI
Low plasma arginine concentrations in children with cerebral malaria and decreased nitric oxide production.
Bert K. Lopansri,Nicholas M. Anstey,J. Brice Weinberg,Gregory J. Stoddard,Maurine R. Hobbs,Marc C. Levesque,Esther D. Mwaikambo,Donald L. Granger +7 more
TL;DR: Nitric oxide (NO) production and mononuclear cell NO synthase 2 (NOS2) expression are high in healthy Tanzanian children but low in those with cerebral malaria, and analysis by logistic regression showed that hypoargininaemia was significantly associatedWith cerebral malaria case-fatality.