Marc Duby

TL;DR: Large-scale loss-of-function screens and TP53 saturation mutagenesis screens in human cancer cell lines suggest that mutational processes combine with phenotypic selection to shape the landscape of somatic mutations at the TP53 locus.

TL;DR: Saturation mutagenesis and prospective experimental characterization can support immediate diagnostic interpretation of newly discovered missense variants in disease-related genes.

TL;DR: The current Translator system, capable of integrating existing biomedical data sets and “translating” those data into insights intended to augment human reasoning and accelerate translational science, is described and compared to state‐of‐the‐art, biomedical graph‐based question‐answering systems.

TL;DR: The Type 2 Diabetes Knowledge Portal (T2DKP) as discussed by the authors is a public resource of genetic datasets and genomic annotations dedicated to type 2 diabetes and related traits, which can be used for access to complex disease genetic results.

TL;DR: The authors examines notions of diaspora under three broad headings: diasporic currents within the country, diasoric flows from "outside" (indentured labor from India for Natal’s sugar plantations), and phenomenological reflections on the interwovenness of place and culture.