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Noël P. Burtt
Researcher at Broad Institute
Publications - 85
Citations - 23094
Noël P. Burtt is an academic researcher from Broad Institute. The author has contributed to research in topics: Genome-wide association study & Single-nucleotide polymorphism. The author has an hindex of 46, co-authored 77 publications receiving 20425 citations. Previous affiliations of Noël P. Burtt include Harvard University & Massachusetts Institute of Technology.
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Journal ArticleDOI
Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes
Siddhartha Jaiswal,Pierre Fontanillas,Jason Flannick,Jason Flannick,Alisa K. Manning,Peter V. Grauman,Brenton G. Mar,Brenton G. Mar,R. Coleman Lindsley,Craig H. Mermel,Noël P. Burtt,Alejandro Chavez,John M. Higgins,Vladislav Moltchanov,Vladislav Moltchanov,Frank C. Kuo,Michael J. Kluk,Brian E. Henderson,Leena Kinnunen,Heikki A. Koistinen,Heikki A. Koistinen,Claes Ladenvall,Gad Getz,Adolfo Correa,Benjamin F. Banahan,Stacey Gabriel,Stacey Gabriel,Sekar Kathiresan,Heather M. Stringham,Mark I. McCarthy,Michael Boehnke,Jaakko Tuomilehto,Jaakko Tuomilehto,Jaakko Tuomilehto,Christopher A. Haiman,Leif Groop,Gil Atzmon,James G. Wilson,Donna Neuberg,David Altshuler,Benjamin L. Ebert +40 more
TL;DR: Age-related clonal hematopoiesis is a common condition that is associated with increases in the risk of hematologic cancer and in all-cause mortality, with the latter possibly due to an increased risk of cardiovascular disease.
Journal ArticleDOI
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
Andrew P. Morris,Benjamin F. Voight,Benjamin F. Voight,Tanya M. Teslovich,Teresa Ferreira,Ayellet V. Segrè,Ayellet V. Segrè,Valgerdur Steinthorsdottir,Rona J. Strawbridge,Hassan Khan,Harald Grallert,Anubha Mahajan,Inga Prokopenko,Hyun Min Kang,Christian Dina,Tõnu Esko,Ross M. Fraser,Stavroula Kanoni,Ashok Kumar,Vasiliki Lagou,Claudia Langenberg,Jian'an Luan,Cecilia M. Lindgren,Martina Müller-Nurasyid,Sonali Pechlivanis,N. William Rayner,Laura J. Scott,S Wiltshire,Loic Yengo,Leena Kinnunen,Elizabeth J. Rossin,Elizabeth J. Rossin,Elizabeth J. Rossin,Soumya Raychaudhuri,Soumya Raychaudhuri,Andrew D. Johnson,Antigone S. Dimas,Antigone S. Dimas,Antigone S. Dimas,Ruth J. F. Loos,Sailaja Vedantam,Sailaja Vedantam,Han Chen,Jose C. Florez,Jose C. Florez,Caroline S. Fox,Caroline S. Fox,Ching-Ti Liu,Denis Rybin,David Couper,Wen Hong L. Kao,Man Li,Marilyn C. Cornelis,Peter Kraft,Qi Sun,Rob M. van Dam,Rob M. van Dam,Heather M. Stringham,Peter S. Chines,Krista Fischer,Pierre Fontanillas,Oddgeir L. Holmen,Sarah E. Hunt,Anne U. Jackson,Augustine Kong,Robert W. Lawrence,Julia Meyer,John R. B. Perry,John R. B. Perry,Carl G. P. Platou,Simon C. Potter,Emil Rehnberg,Neil Robertson,Suthesh Sivapalaratnam,Alena Stančáková,Kathleen Stirrups,Gudmar Thorleifsson,Emmi Tikkanen,Emmi Tikkanen,Andrew R. Wood,Peter Almgren,Mustafa Atalay,Rafn Benediktsson,Lori L. Bonnycastle,Noël P. Burtt,Jason Carey,Guillaume Charpentier,Andrew Crenshaw,Alex S. F. Doney,Mozhgan Dorkhan,Sarah Edkins,Valur Emilsson,Elodie Eury,Tom Forsén,Karl Gertow,Bruna Gigante,George B. Grant,Christopher J. Groves,Candace Guiducci,Christian Herder,Astradur B. Hreidarsson,Jennie Hui,Jennie Hui,Alan James,Alan James,Anna Jonsson,Wolfgang Rathmann,Norman Klopp,Jasmina Kravic,Kaarel Krjutškov,Cordelia Langford,Karin Leander,Eero Lindholm,Stéphane Lobbens,Satu Männistö,Ghazala Mirza,Thomas W. Mühleisen,Bill Musk,Bill Musk,Melissa Parkin,Loukianos S. Rallidis,Jouko Saramies,Bengt Sennblad,Sonia Shah,Gunnar Sigurðsson,Angela Silveira,Gerald Steinbach,Barbara Thorand,Joseph Trakalo,Fabrizio Veglia,Roman Wennauer,Wendy Winckler,Delilah Zabaneh,Harry Campbell,Cornelia M. van Duijn,André G. Uitterlinden,Albert Hofman,Eric J.G. Sijbrands,Gonçalo R. Abecasis,Katharine R. Owen,Eleftheria Zeggini,Mieke D. Trip,Nita G. Forouhi,Ann-Christine Syvänen,Johan G. Eriksson,Johan G. Eriksson,Leena Peltonen,Markus M. Nöthen,Beverley Balkau,Colin N. A. Palmer,Valeriya Lyssenko,Tiinamaija Tuomi,Bo Isomaa,David J. Hunter,Lu Qi,Alan R. Shuldiner,Alan R. Shuldiner,Michael Roden,Inês Barroso,Tom Wilsgaard,John Beilby,John Beilby,Kees Hovingh,Jackie F. Price,James F. Wilson,Rainer Rauramaa,Timo A. Lakka,Lars Lind,George Dedoussis,Inger Njølstad,Nancy L. Pedersen,Kay-Tee Khaw,Nicholas J. Wareham,Sirkka Keinänen-Kiukaanniemi,Timo Saaristo,Eeva Korpi-Hyövälti,Juha Saltevo,Markku Laakso,Johanna Kuusisto,Andres Metspalu,Francis S. Collins,Karen L. Mohlke,Richard N. Bergman,Jaakko Tuomilehto,Bernhard O. Boehm,Christian Gieger,Kristian Hveem,Stéphane Cauchi,Philippe Froguel,Philippe Froguel,Damiano Baldassarre,Elena Tremoli,Steve E. Humphries,Danish Saleheen,John Danesh,Erik Ingelsson,Samuli Ripatti,Samuli Ripatti,Samuli Ripatti,Veikko Salomaa,Raimund Erbel,Karl-Heinz Jöckel,Susanne Moebus,Annette Peters,Thomas Illig,Ulf de Faire,Anders Hamsten,Andrew D. Morris,Peter Donnelly,Timothy M. Frayling,Andrew T. Hattersley,Eric Boerwinkle,Eric Boerwinkle,Olle Melander,Sekar Kathiresan,Sekar Kathiresan,Peter M. Nilsson,Panos Deloukas,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Leif Groop,Kari Stefansson,Kari Stefansson,Frank B. Hu,James S. Pankow,Josée Dupuis,Josée Dupuis,James B. Meigs,James B. Meigs,David Altshuler,David Altshuler,Michael Boehnke,Mark I. McCarthy +232 more
TL;DR: This article conducted a meta-analysis of genetic variants on the Metabochip, including 34,840 cases and 114,981 controls, overwhelmingly of European descent, and identified ten previously unreported T2D susceptibility loci, including two showing sex-differentiated association.
Journal ArticleDOI
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
Cristen J. Willer,Elizabeth K. Speliotes,Elizabeth K. Speliotes,Ruth J. F. Loos,Shengxu Li,Cecilia M. Lindgren,Iris M. Heid,Sonja I. Berndt,Amanda F. Elliott,Amanda F. Elliott,Anne U. Jackson,Claudia Lamina,Guillaume Lettre,Guillaume Lettre,Noha Lim,Helen N. Lyon,Helen N. Lyon,Steven A. McCarroll,Steven A. McCarroll,Konstantinos A. Papadakis,Lu Qi,Joshua C. Randall,Rosa Maria Roccasecca,Serena Sanna,Paul Scheet,Michael N. Weedon,Eleanor Wheeler,Jing Hua Zhao,Leonie C. Jacobs,Inga Prokopenko,Nicole Soranzo,Nicole Soranzo,Toshiko Tanaka,Nicholas J. Timpson,Peter Almgren,Amanda J. Bennett,Richard N. Bergman,Sheila Bingham,Lori L. Bonnycastle,Morris Brown,Noël P. Burtt,Peter S. Chines,Lachlan J. M. Coin,Francis S. Collins,John M. C. Connell,Cyrus Cooper,George Davey Smith,Elaine M. Dennison,Parimal Deodhar,Paul Elliott,Michael R. Erdos,Karol Estrada,David M. Evans,Lauren Gianniny,Christian Gieger,Christopher J. Gillson,Candace Guiducci,Rachel Hackett,David Hadley,Alistair S. Hall,Aki S. Havulinna,Johannes Hebebrand,Albert Hofman,Bo Isomaa,Kevin B. Jacobs,Toby Johnson,Toby Johnson,Pekka Jousilahti,Zorica Jovanovic,Zorica Jovanovic,Kay-Tee Khaw,Peter Kraft,Mikko Kuokkanen,Mikko Kuokkanen,Johanna Kuusisto,Jaana Laitinen,Edward G. Lakatta,Jian'an Luan,Robert Luben,Massimo Mangino,Wendy L. McArdle,Thomas Meitinger,Antonella Mulas,Patricia B. Munroe,Narisu Narisu,Andy R Ness,Kate Northstone,Stephen O'Rahilly,Stephen O'Rahilly,Carolin Purmann,Carolin Purmann,Matthew G. Rees,Martin Ridderstråle,Susan M. Ring,Fernando Rivadeneira,Aimo Ruokonen,Manjinder S. Sandhu,Manjinder S. Sandhu,Jouko Saramies,Laura J. Scott,Angelo Scuteri,Kaisa Silander,Matthew A. Sims,Kijoung Song,Jonathan Stephens,Suzanne Stevens,Heather M. Stringham,Y. C. Loraine Tung,Y. C. Loraine Tung,Timo T. Valle,Cornelia M. van Duijn,Karani Santhanakrishnan Vimaleswaran,Karani Santhanakrishnan Vimaleswaran,Peter Vollenweider,Gérard Waeber,Chris Wallace,Richard M. Watanabe,Dawn M. Waterworth,Nicholas A. Watkins,Jacqueline C. M. Witteman,Eleftheria Zeggini,Guangju Zhai,M. Carola Zillikens,David Altshuler,David Altshuler,Mark J. Caulfield,Stephen J. Chanock,I. Sadaf Farooqi,I. Sadaf Farooqi,Luigi Ferrucci,Jack M. Guralnik,Andrew T. Hattersley,Frank B. Hu,Marjo-Riitta Järvelin,Markku Laakso,Vincent Mooser,Ken K. Ong,Willem H. Ouwehand,Willem H. Ouwehand,Veikko Salomaa,Nilesh J. Samani,Tim D. Spector,Tiinamaija Tuomi,Jaakko Tuomilehto,Manuela Uda,André G. Uitterlinden,Nicholas J. Wareham,Panagiotis Deloukas,Timothy M. Frayling,Leif Groop,Leif Groop,Richard B. Hayes,David J. Hunter,David J. Hunter,Karen L. Mohlke,Leena Peltonen,Leena Peltonen,Leena Peltonen,David Schlessinger,David P. Strachan,H-Erich Wichmann,Mark I. McCarthy,Michael Boehnke,Inês Barroso,Gonçalo R. Abecasis,Joel N. Hirschhorn,Joel N. Hirschhorn +166 more
TL;DR: Several of the likely causal genes are highly expressed or known to act in the central nervous system (CNS), emphasizing, as in rare monogenic forms of obesity, the role of the CNS in predisposition to obesity.
Journal ArticleDOI
Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans.
Sekar Kathiresan,Sekar Kathiresan,Olle Melander,Candace Guiducci,Aarti Surti,Noël P. Burtt,Mark J. Rieder,Gregory M. Cooper,Charlotta Roos,Benjamin F. Voight,Benjamin F. Voight,Aki S. Havulinna,Björn Wahlstrand,Thomas Hedner,Dolores Corella,E. Shyong Tai,Jose M. Ordovas,Göran Berglund,Erkki Vartiainen,Pekka Jousilahti,Bo Hedblad,Marja-Riitta Taskinen,Christopher Newton-Cheh,Christopher Newton-Cheh,Veikko Salomaa,Leena Peltonen,Leif Groop,Leif Groop,David Altshuler,Marju Orho-Melander +29 more
TL;DR: Using genome-wide association data from three studies and targeted replication association analyses in up to 18,554 independent participants, it is shown that common SNPs at 18 loci are reproducibly associated with concentrations of low-density cholesterol, high-density lipoprotein (HDL) cholesterol, and/or triglycerides.
Journal ArticleDOI
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci
Eli A. Stahl,Soumya Raychaudhuri,Soumya Raychaudhuri,Elaine F. Remmers,Gang Xie,Stephen Eyre,Brian Thomson,Yonghong Li,Fina A S Kurreeman,Fina A S Kurreeman,Fina A S Kurreeman,Alexandra Zhernakova,Anne Hinks,Candace Guiducci,Robert Chen,Lars Alfredsson,Christopher I. Amos,Kristin G. Ardlie,Anne Barton,John Bowes,Elisabeth Brouwer,Noël P. Burtt,Joseph J. Catanese,Jonathan S. Coblyn,Marieke J H Coenen,Karen H. Costenbader,Lindsey A. Criswell,J. Bart A. Crusius,Jing Cui,Paul I.W. de Bakker,Paul I.W. de Bakker,Philip L. De Jager,Philip L. De Jager,Bo Ding,Paul Emery,Edward Flynn,Pille Harrison,Lynne J. Hocking,Tom W J Huizinga,Daniel L. Kastner,Xiayi Ke,Annette Lee,Xiangdong Liu,Paul Martin,Ann W. Morgan,Leonid Padyukov,Marcel D. Posthumus,Timothy R D J Radstake,David M. Reid,Mark Seielstad,Michael F. Seldin,Nancy A. Shadick,Sophia Steer,Paul P. Tak,Wendy Thomson,Annette H M van der Helm-van Mil,Irene E. van der Horst-Bruinsma,C. Ellen van der Schoot,Piet L. C. M. van Riel,Michael E. Weinblatt,Anthony G. Wilson,Gertjan Wolbink,B. Paul Wordsworth,Cisca Wijmenga,Elizabeth W. Karlson,René E. M. Toes,Niek de Vries,Ann B. Begovich,Ann B. Begovich,Jane Worthington,Katherine A. Siminovitch,Peter K. Gregersen,Lars Klareskog,Robert M. Plenge,Robert M. Plenge +74 more
TL;DR: Seven new rheumatoid arthritis risk alleles were identified at genome-wide significance (P < 5 × 10−8) in an analysis of all 41,282 samples, and an additional 11 SNPs replicated at P < 0.05, suggesting that most represent genuine rhearatoid arthritisrisk alleles.